Reducing the Size and Cost of MRI by Using a Zero-He Moderate-Field MRI Magnet Integrated with a Cryocooled RF Coil

通过使用与低温冷却射频线圈集成的零氦中场 MRI 磁体来减小 MRI 的尺寸和成本

• 批准号: 10081755
• 负责人: Shahin Pourrahimi
• 金额: $ 25.21万
• 依托单位: SUPERCONDUCTING SYSTEMS, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10081755
• 关键词: Adopted; Advanced Development; Ambulances; Applications Grants; Architecture; Beds; Devices; Economics; Funding; Goals; Head; Heart; International; Intervention; Limb structure; Magnetic Resonance Imaging; Manufacturer Name; Measurement; Measures; Medical Device; Noise; Operating Rooms; Performance; Phase; RF coil; Research; Resistance; Scanning; Ships; Signal Transduction; Small Business Innovation Research Grant; Sports; System; Technology; Temperature; Testing; Time; Work; cost; cryostat; design; innovation; point of care; programs; trend

Abstract: This application proposes to demonstrate that the more economic cryogen-free magnets operating at moderate fields of 0.5T-1T, and integrated with cryocooled RF coils, can produce signal to noise ratios (SNR) that are potentially comparable to those of 1.5 T MRI scanners with conventional RF coils. This project paves the way towards high-performance, smaller size, and lower cost MRI scanners suited to the emerging interventional and point-of-care applications. It is well established that reducing the RF coil resistance by cooling is advantageous for either small coils or low fields. Because the required scan time decreases in proportion to the square of SNR, even modest improvements in SNR are highly advantageous, especially in interventional and point-of-care situations. The first Aim of the Phase I effort is to demonstrate the feasibility of obtaining significantly higher SNR by conduction-cooling of RF receive coils, and establish the tradeoffs between field strength, magnet size (cost), and SNR gained by cryocooling of the RF receive coil. The second Aim of Phase I is to use results of this tradeoff study to design a practical cryogen-free magnet for head-MRI that includes an integrated cryocooled RF receive coil that will be built in Phase II of this work. The addition of cryocooled RF receive coils (higher SNR) to the magnet is provided at a small incremental cost to the magnet system. SSI, the applicant, has a proven record in the development of advanced cryogen-free MRI magnets under SBIR funding, and several international medical device companies have adopted (licensed) SSI’s MRI cryogen-free magnet technology.

摘要： 本申请旨在证明更经济的无冷冻剂磁体 在0.5T-1 T的中等磁场下工作，并与低温冷却的RF线圈集成，可以产生 信噪比（SNR）可能与1.5 T MRI扫描仪相当， 常规RF线圈。该项目为实现高性能、更小尺寸和 低成本MRI扫描仪，适合新兴的介入和床旁应用。它 通过冷却来降低RF线圈电阻对于以下两种情况都是有利的 小线圈或低磁场。因为所需的扫描时间与平方成比例地减少， 的SNR，即使SNR的适度改善也是非常有利的，特别是在 介入和即时护理情况。第一阶段工作的第一个目标是证明 通过RF接收线圈的传导冷却获得显著更高SNR的可行性， 并建立场强、磁体尺寸（成本）和SNR之间的权衡， RF接收线圈的低温冷却。第一阶段的第二个目标是使用这种权衡的结果 研究设计一个实用的无致冷剂磁体头部MRI，包括集成 低温冷却射频接收线圈，将建立在第二阶段的这项工作。添加低温冷却 RF接收线圈（更高的SNR）到磁体是以小的增量成本提供的。 磁铁系统SSI，申请人，在开发先进的 SBIR资助的无冷冻剂MRI磁体，以及几种国际医疗器械 公司已采用（授权）SSI的MRI无冷冻剂磁体技术。