Mechanisms of memory function involving site-specific tau phosphorylation

涉及位点特异性 tau 磷酸化的记忆功能机制

• 批准号: DP200102396
• 负责人: A/Prof Arne Ittner
• 金额: $ 56.22万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2024-10-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102396
• 关键词: Mechanisms; memory; function; involving; site

This project aims to understand the molecular principles that facilitate encoding, maintenance and retrieval of memories in the brain. To store memories in brain circuits, electrical and chemical signals are crucial. Brain cells can integrate signals into biochemical modifications of intracellular proteins. The nature of the protein modifications that represent memory within brain cells is unknown. This project uses innovative genome editing, mathematical modelling and proteomic approaches, to study how biochemical modifications of a key protein called tau help encode and retrieve memories. These molecular insights will make a significant advance in the current understanding of a brain function that is essential to all human activities.

该项目旨在了解促进大脑记忆编码、维护和检索的分子原理。为了在大脑回路中存储记忆，电信号和化学信号至关重要。脑细胞可以将信号整合到细胞内蛋白质的生化修饰中。代表脑细胞内记忆的蛋白质修饰的性质尚不清楚。该项目使用创新的基因组编辑、数学模型和蛋白质组学方法，研究 tau 关键蛋白的生化修饰如何帮助编码和检索记忆。这些分子见解将在当前对所有人类活动至关重要的大脑功能的理解方面取得重大进展。