FT MASS SPECTROMETRY FOR BIOMOLECULE ANALYSIS
FT MASS SPECTROMETRY FOR BIOMOLECULE ANALYSIS
批准号:
2176255
负责人:
ALAN G MARSHALL
金额:
$17.9万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1993
资助国家:
美国
项目状态:
已结题
起止时间:
1993-11-01 至 1997-06-30
关键词:
bioengineering /biomedical engineering biomedical equipment development carbohydrate structure chemical structure computer simulation interferometry ion cyclotron resonance spectrometry ionization ions lasers macromolecule magnetic field mass spectrometry oligosaccharides protein structure structural biology superconductivity
中文摘要
描述:(改编自申请人的摘要)提议
英文摘要
DESCRIPTION: (Adapted from the applicant's abstract) It is proposed to
design, construct, test, and systematically refine a state-of-the-art
Fourier transform ion cyclotron resonance mass spectrometer built around
a 9.4 tesla superconducting magnet. The instrument will optimized for
unsurpassed sensitivity, mass resolution, and mass accuracy for singly-
and multiply- charged macromolecular ions up to 150,000 dalton. The
instrument will incorporate the following features: electrospray, Cs+
liquid secondary ion, and matrix-assisted laser desorption ion sources;
a novel ion transfer and trapping method; stored wave form dual-channel
broadband dipolar and quadrupolar excitation; fast data acquisition and
processing for wide mass range at high mass resolving power; and rf-
linearized ion trap for increased upper mass limit, more accurate mass
measurement, and more accurate ion relative abundances, higher-
resolution MS/MS performance, increased dynamic range, and linearized
detection. Theoretical numerical simulations will be used to determine
the mechanism(s) for ion trapping and mass spectral line- broadening for
high-mass ions (particularly singly-charged ions), including applied
static and rf electric field, fully mapped magnetic field, and coulomb
forces between ions. The results of those tests will guide the design
of ion injection, ion trapping, and excitation/detection techniques
designed to optimize high-mass ion analysis. Applications for these
technical developments include identification, sequencing, and structural
analysis of phospholipids, oligosaccharides, proteins, oligonucleotides,
and complex unseparated mixtures.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Structural Mapping of Protein Complexes by Hydrogen/Deuterium Exchange
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批准号:7135456
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项目类别:
-
资助金额:$31.48万
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财政年份:2006
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负责人:ALAN G MARSHALL
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依托单位:
Structural Mapping of Protein Complexes by Hydrogen/Deuterium Exchange
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批准号:7267750
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项目类别:
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资助金额:$30.54万
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财政年份:2006
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负责人:ALAN G MARSHALL
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依托单位:
Structural Mapping of Protein Complexes by Hydrogen/Deuterium Exchange
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批准号:7477229
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项目类别:
-
资助金额:$30.51万
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财政年份:2006
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负责人:ALAN G MARSHALL
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依托单位:
Structural Mapping of Protein Complexes by Hydrogen/Deuterium Exchange
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批准号:7665154
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项目类别:
-
资助金额:$30.48万
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财政年份:2006
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负责人:ALAN G MARSHALL
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依托单位:
MAPPING SURFACE CONTACTS IN BIOMACROMOLECULE COMPLEXES
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批准号:6018571
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项目类别:
-
资助金额:$18.53万
-
财政年份:1993
-
负责人:ALAN G MARSHALL
-
依托单位:
FT MASS SPECTROMETRY FOR BIOMOLECULE ANALYSIS
-
批准号:2176256
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项目类别:
-
资助金额:$16.14万
-
财政年份:1993
-
负责人:ALAN G MARSHALL
-
依托单位:
FT MASS SPECTROMETRY FOR BIOMOLECULE ANALYSIS
-
批准号:2176254
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项目类别:
-
资助金额:$27.29万
-
财政年份:1993
-
负责人:ALAN G MARSHALL
-
依托单位:
MAPPING SURFACE CONTACTS IN BIOMACROMOLECULE COMPLEXES
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批准号:6179623
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项目类别:
-
资助金额:$19.0万
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财政年份:1993
-
负责人:ALAN G MARSHALL
-
依托单位:
MAPPING SURFACE CONTACTS IN BIOMACROMOLECULE COMPLEXES
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批准号:2701509
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项目类别:
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资助金额:$18.1万
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财政年份:1993
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负责人:ALAN G MARSHALL
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依托单位:
FT MASS SPECTROMETRY FOR BIOMOLECULE ANALYSIS
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批准号:2615775
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项目类别:
-
资助金额:$4.63万
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财政年份:1993
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负责人:ALAN G MARSHALL
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依托单位:
GAS CHROMATOGRAPH/MASS SPECTROMETER
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批准号:3520861
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项目类别:
-
资助金额:$36.5万
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财政年份:1990
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负责人:ALAN G MARSHALL
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依托单位:
ULTRAHIGH PERFORMANCE MASS SPECTROMETER
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批准号:3519635
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项目类别:
-
资助金额:$30.0万
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财政年份:1987
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负责人:ALAN G MARSHALL
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依托单位:
STOCHASTIC FT ION CYCLOTRON RESONANCE MASS SPECTROMETRY
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批准号:3279918
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项目类别:
-
资助金额:$13.39万
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财政年份:1983
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负责人:ALAN G MARSHALL
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依托单位:
STOCHASTIC FT ION CYCLOTRON RESONANCE MASS SPECTROMETRY
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批准号:3279917
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项目类别:
-
资助金额:$12.68万
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财政年份:1983
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负责人:ALAN G MARSHALL
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依托单位:
STOCHASTIC FT ION CYCLOTRON RESONANCE MASS SPECTROMETRY
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批准号:3279910
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项目类别:
-
资助金额:$24.44万
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财政年份:1983
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负责人:ALAN G MARSHALL
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依托单位:
FT MASS SPECTROMETRY FOR BIOMOLECULE ANALYSIS
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批准号:3279919
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项目类别:
-
资助金额:$15.85万
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财政年份:1983
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负责人:ALAN G MARSHALL
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依托单位:
FT MASS SPECTROMETRY FOR BIOMOLECULE ANALYSIS
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批准号:3279920
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项目类别:
-
资助金额:$3.3万
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财政年份:1983
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负责人:ALAN G MARSHALL
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依托单位:
FT MASS SPECTROMETRY FOR BIOMOLECULE ANALYSIS
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批准号:3279921
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项目类别:
-
资助金额:$13.4万
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财政年份:1983
-
负责人:ALAN G MARSHALL
-
依托单位:
STOCHASTIC FT ION CYCLOTRON RESONANCE MASS SPECTROMETRY
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批准号:3279916
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项目类别:
-
资助金额:$12.35万
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财政年份:1983
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负责人:ALAN G MARSHALL
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依托单位:
STOCHASTIC FOURIER TRANSFORM ION CYCLOTRON RESONANCE
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批准号:3279915
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项目类别:
-
资助金额:$7.84万
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财政年份:1983
-
负责人:ALAN G MARSHALL
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依托单位: