随机傅里叶变换离子回旋共振-猫眼课题宝

随机傅里叶变换离子回旋共振

批准号：

3279915

负责人：

ALAN G MARSHALL

金额：

$7.84万

依托单位：

OHIO STATE UNIVERSITY

依托单位国家：

美国

项目类别：

财政年份：

1983

资助国家：

美国

项目状态：

已结题

起止时间：

1983-04-01 至 1986-03-31

来源：

https://reporter.nih.gov/project-details/3279915

关键词：

Reye's syndrome alpha antiadrenergic agent amniotic fluid aniline anticonvulsants antihyperlipoproteinemic agent beta adrenergic agent biomedical automation blood chemistry body fluids cardiotonic agents clinical biomedical equipment clinical chemistry computer assisted diagnosis drug administration rate /duration drug adverse effect drug metabolism drug screening /evaluation embryo /fetus pharmacology embryo /fetus toxicology environmental toxicology female reproductive system disorder gas chromatography gastrointestinal drug absorption genital secretion high performance liquid chromatography human tissue interferometry ion cyclotron resonance spectrometry mass spectrometry molecular pathology muscle relaxants noninvasive diagnosis phenytoin placental transfer prenatal diagnosis prenatal growth disorder propranolol prostaglandins thin layer chromatography toxicant screening umbilical cord unsaturated fatty acids urinalysis

中文摘要

翻译

一种激发和探测离子回旋共振的新方法提出了质谱。激励由以下时间序列组成：具有伪随机相位的等宽度、等幅度和等间隔的脉冲变化量对于给定的质量/电荷（m/z）范围，激发可以是量身定做，让人兴奋，所有，除了一个，...，两个或一个m/z值，范围由于分时检测与激励同时进行，随机方法在激发中提供更大的选择性，简化定相导致增加的质量分辨率，更均匀的峰高，动态范围更大，真正同时进行多离子监测， MS/MS和其他应用。其他具体建议包括：一种减少（因子20）所需内存量的方法，存储FT-ICR质谱，各种阵列处理器应用，非线性数据采样以实现更高效的数据存储，校正，自动调整程序，多维光谱显示器和其他。

英文摘要

A new method for exciting and detecting an ion cyclotron resonance (ICR) mass spectrum is proposed. The excitation consists of a time sequence of pulses of equal width, amplitude, and spacing, with pseudorandom phase variation. For a given mass/charge (m/z) range, the excitation can be tailored to excite, all, all but one, ..., two, or one m/z-value in the range. Since time-shared detection is simultaneous with excitation, the stochastic method provides greater selectivity in excitation, simplified phasing leading to increased mass resolution, more uniform peak heights, increased dynamic range, and truly simultaneous multiple-ion monitoring for MS/MS and other applications. Additional specific proposals include a method for reducing (by a factor of 20) the amount of memory needed to store FT-ICR mass spectra, various array processor applications, non-linear data sampling for more efficient data storage, improvements in phase correction, automated tune-up procedures, multidimensional spectral displays, and others.

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