Surface engineering and coating of polymer templates for metal microneedle array fabrication

用于金属微针阵列制造的聚合物模板的表面工程和涂层

• 批准号: 132884
• 金额: $ 11.08万
• 依托单位: PICOFLUIDICS LIMITED
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=132884
• 关键词: Surface; engineering; coating; polymer; templates

Microneedles (MNs) , small needles typically about 100 - 1000µm long, are one of the most promising ways forachieving trasdermal delivery of drugs & the removal of bodily fluids. MNs allow virtually pain free insertioninto the skin; can be used by untrained personnel & deliver drugs very efficiently. However the cost ofmanufacturing these devices is limiting the adoption of this emerging technology. Using a highly innovative,and potentially World leading, surface engineering approach, we aim to develop and carry out a proof ofconcept test of a new low cost MN manufacturing process which is based upon the selective surface treatmentof polymer templates which will then provide the sites for metal MN growth. The MN arrays, multiple MNsat ~ 1mm pitch, are then released from the template. Picofluidics (PICO)and Coventry University (COV) willdevelop and implement process steps to make solid and hollow metal MNs and characterise small arrays ofrepresentative devices. Using an equivalent Si micromachined device as a benchmark we aim to demonstrate>66% reduction in cost through the use of this novel approach.Finance Summary Table – How to complete this section

微针（MN），通常约100 - 1000µm长的小针，是实现药物经皮递送和体液清除的最有前途的方法之一。MN允许几乎无痛插入皮肤;可以由未经培训的人员使用，并非常有效地输送药物。然而，制造这些设备的成本限制了这一新兴技术的采用.使用高度创新的，潜在的世界领先的表面工程方法，我们的目标是开发和进行一个新的低成本MN制造工艺的概念验证测试，该工艺基于聚合物模板的选择性表面处理，然后为金属MN生长提供场所。然后从模板释放MN阵列，多个MNsat ~ 1 mm间距。Picofluidics（皮科）和考文垂大学（COV）将开发和实施工艺步骤，以制造实心和空心金属MN和小型代表性设备阵列。使用等效的硅微机械器件作为基准，我们的目标是通过使用这种新方法来证明成本降低>66%。财务汇总表-如何填写本部分