Molecular probes for selective sensing of membrane phospholipids

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The goal of this project is to develop a toolkit of molecular probes that are able to selectively bind to the phospholipids that constitute a large part of biological membranes. Membranes are composed of over one thousand structurally different lipid molecules but we do not have a clear understanding of how these structural differences impact on cell function. This project will provide new tools that can be applied to expand our knowledge of the impact of lipid diversity on biological function. This will underpin advances throughout cell biology. It will provide new opportunities for interdisciplinary collaboration between synthetic chemists and cell biologists.