Novel Synthetic Receptors for Recognition and Transport of Biologically Important Anions

用于识别和运输具有重要生物学意义的阴离子的新型合成受体

• 批准号: DP140100227
• 负责人: Prof Katrina Jolliffe
• 金额: $ 23.07万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140100227
• 关键词: Novel; Synthetic; Receptors; Recognition; Transport

Anion receptors are not currently tailored for the ‘real world’ biological environments (for example, physiological saline and membranes) in which anions perform their many critical roles. The project will design and synthesise a range of molecular receptors based on large, rigid, precisely functionalisable scaffolds, tailored specifically to complement both the shape, size and charge of target anions as well as their native environment. The project will investigate the ability of these receptors to strongly bind their target anions with high selectivity in both aqueous systems and in membrane environments. This will lead to the development of innovative synthetic receptors that recognise and/or transport biological anions for use in biomedical applications.

阴离子受体目前并不适合于“真实的世界”的生物环境（例如，生理盐水和膜），其中阴离子发挥其许多关键作用。该项目将设计和合成一系列基于大型，刚性，精确功能化支架的分子受体，专门针对目标阴离子的形状，大小和电荷以及它们的天然环境进行定制。该项目将研究这些受体在水体系和膜环境中以高选择性强烈结合其目标阴离子的能力。这将导致开发创新的合成受体，识别和/或运输生物阴离子，用于生物医学应用。