Novel Synthetic Receptors For Selective Recognition of Phosphate Oxoanions

用于选择性识别磷酸根含氧阴离子的新型合成受体

• 批准号: DP0877726
• 负责人: Prof Katrina Jolliffe
• 金额: $ 23.45万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-02-14 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0877726
• 关键词: Novel; Synthetic; Receptors; Selective; Recognition

Anions are critical to the maintenance of life, playing roles in almost every biochemical process. Artificial anion receptors that bind strongly to specific anions have considerable potential applications in biomedicine, but current receptors do not possess the required selectivity for applications. We will undertake the design and construction of a number of molecular receptors tailored to complement the size, shape and charge of specific biologically important anions and will assess their ability to bind selectively to their target guests. This will lead to the development of small molecule receptors for use in biomedical applications.

阴离子对维持生命至关重要，几乎在每一个生化过程中发挥作用。人工阴离子受体与特异性阴离子结合能力强，在生物医学领域有着广泛的应用前景，但目前的受体不具备应用所需的选择性。我们将设计和构建一些分子受体，以补充特定生物学重要阴离子的大小，形状和电荷，并评估它们选择性结合目标客人的能力。这将导致用于生物医学应用的小分子受体的开发。