Novel Synthetic Receptors For Selective Recognition of Phosphate Oxoanions

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Anions are critical to the maintenance of life, playing roles in almost every biochemical process. Artificial anion receptors that bind strongly to specific anions have considerable potential applications in biomedicine, but current receptors do not possess the required selectivity for applications. We will undertake the design and construction of a number of molecular receptors tailored to complement the size, shape and charge of specific biologically important anions and will assess their ability to bind selectively to their target guests. This will lead to the development of small molecule receptors for use in biomedical applications.