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ASSEMBLY AND STRUCTURE OF BACTERIOPHAGE LAMBDA

ASSEMBLY AND STRUCTURE OF BACTERIOPHAGE LAMBDA
噬菌体 Lambda 的组装和结构
批准号：
2185197
负责人：
ROGER W HENDRIX
金额：
$23.68万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1977
资助国家：
美国
项目状态：
已结题
起止时间：
1977-12-01 至 1995-08-31
来源：
https://reporter.nih.gov/project-details/2185197
关键词：
Escherichia coli X ray crystallography bacteriophage lambda binding proteins carbon chemical cleavage chemical fingerprinting electron microscopy electrophoresis gene expression genetic manipulation genetic mapping genetic promoter element genetic transcription high performance liquid chromatography host organism interaction immunochemistry immunoelectron microscopy microorganism culture microorganism metabolism molecular cloning monoclonal antibody mutant nucleic acid sequence phosphorus protein biosynthesis protein sequence proteins radionuclides radiotracer stoichiometry tritium virion virus envelope virus genetics virus protein virus replication

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中文摘要
翻译
这项研究旨在了解生物组装 利用噬菌体的组装， λ病毒粒子作为模型。 该研究的重点是装配过程中， 一种蛋白质影响或指导另一种蛋白质的组装， 了解这些事件背后的详细机制。 具体 正在解决的问题包括E. 大肠杆菌GroE蛋白，其是正确的病毒所需的宿主蛋白 组装，在病毒组装过程中蛋白质加工的性质和作用， 以及尾部卷尺蛋白决定尾部的机制 长度
英文摘要
This research is directed toward understanding biological assembly processes at the molecular level, using assembly of the bacteriophage lambda virion as a model. The research focuses on assembly processes in which one protein influences or directs the assembly of another, and seeks to understand the detailed mechanisms behind such events. Specific problems being addressed include the structure and regulation of the E. coli GroE proteins, which are host proteins required for correct virus assembly, the nature and role of protein processing during virus assembly, and the mechanisms by which the tail tape measure protein determines tail length.
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STRUCTURE & FUNCTION OF BACTERIAL VIRUSES
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