STRUCTURE-FUNCTION RELATIONSHIPS IN HEMOGLOBIN AND ERYTHROCYTES

本项目侧重于涉及的机制， 调节氧与血红蛋白的结合， 将氧气输送到组织。 重点 这些功能受损和改变的方式 随年龄 这些研究集中在氧化的 血红蛋白，产生非功能性血红蛋白， 同时释放氧自由基。 增强 在低氧条件下的这些氧化过程中， 作为组织和器官的可能来源 在衰老过程中会加剧。 研究 也包括针对稳定性的 整个红细胞和红细胞膜。

This project focuses on the mechanism involved in regulating the binding of oxygen to hemoglobin and the transport of oxygen to the tissues. Emphasis is placed on ways in which these functions are impaired and change with age. These studies have focused on the oxidation of hemoglobin, which produces nonfunctional hemoglobin and the simultaneous release of oxyradicals. The enhancement of these oxidative processes under hypoxic conditions is being explored as a possible source of tissue and organ damage, which would be exacerbated during aging. Studies are also included which are directed at the stability of the entire erythrocyte and the erythrocyte membrane.