STRUCTURE-FUNCTION RELATIONSHIPS IN HEMOGLOBIN AND ERYTHROCYTES

工作概要：本项目侧重于 调节氧与血红蛋白的结合和氧的运输 到组织。 重点放在这些职能的方式， 随着年龄的增长而变化。 这些研究集中在氧化 血红蛋白，产生非功能性血红蛋白， 同时释放氧自由基。 增强这些氧化 在低氧条件下的过程正在探索作为一个可能的来源， 组织和器官的损伤，这将在衰老过程中加剧。 还包括针对药物稳定性的研究。 整个红细胞和红细胞膜。动物和人类研究 以调查可能的功能障碍， 红细胞损伤

Summary of work: This project focuses on the mechanism involved in regulating the binding of oxygen to hemoglobin and the transport of oxygen to the tissues. Emphasis is placed on ways in which these functions are impaired and change with age. These studies have focused on the oxidation of hemoglobin, which produces nonfunctional hemoglobin and the simultaneous release of oxyradicals. The enhancement of these oxidative processes under hypoxic conditions is being explored as a possible source of tissue and organ damage, which would be exacerbated during aging. Studies are also included which are directed at the stability of the entire erythrocyte and the erythrocyte membrane. Animal and human studies are performed to investigate possible functional impairment associated with red cell damage.