STRUCTURE-FUNCTION RELATIONSHIPS IN HEMOGLOBIN AND ERYTHROCYTES

本项目的重点是调节绑定的机制。 氧气到血红蛋白和氧气到组织的运输。 重点放在这些功能受到损害的方式和 随着年龄的增长而改变。这些研究的重点是氧化 产生无功能血红蛋白的血红蛋白和同时 氧自由基的释放。这些氧化过程的增强 在低氧条件下作为一种可能的组织来源被探索 以及器官损伤，这在衰老过程中会加剧。研究是 还包括了针对整个 红细胞膜和红细胞膜。

This project focuses on the mechanism involved in regulating the binding of oxygen to hemoglobin and the transport of oxygen to the tissues. Emphasis is placed on ways in which these functions are impaired and change with age. These studies have focused on the oxidation of hemoglobin, which produces nonfunctional hemoglobin and the simultaneous release of oxyradicals. The enhancement of these oxidative processes under hypoxic conditions is being explored as a possible source of tissue and organ damage, which would be exacerbated during aging. Studies are also included which are directed at the stability of the entire erythrocyte and the erythrocyte membrane.