STRUCTURE-FUNCTION RELATIONSHIPS IN HEMOGLOBIN AND ERYTHROCYTES

本项目的重点是调节 氧与血红蛋白的结合和氧向 纸巾。重点放在这些功能是如何 受损，并随年龄变化。这些研究的重点是 氧化血红蛋白，从而产生无功能的血红蛋白和 氧自由基的同时释放。这些功能的增强 低氧条件下的氧化过程正在作为一种 组织和器官损害的可能来源，这将加剧 在衰老过程中。研究也被包括在针对 整个红血球和红细胞膜的稳定性。

This project focuses on the mechanism involved in regulating the binding of oxygen to hemoglobin and the transport of oxygen to the tissues. Emphasis is placed on ways in which these functions are impaired and change with age. These studies have focused on the oxidation of hemoglobin, which produces nonfunctional hemoglobin and the simultaneous release of oxyradicals. The enhancement of these oxidative processes under hypoxic conditions is being explored as a possible source of tissue and organ damage, which would be exacerbated during aging. Studies are also included which are directed at the stability of the entire erythrocyte and the erythrocyte membrane.