Genetic and Molecular Consequences of Non-Random Mating in Humans

人类非随机交配的遗传和分子后果

• 批准号: DE200100425
• 负责人: A/Prof Loic Yengo
• 金额: $ 28.12万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE200100425
• 关键词: Genetic; Molecular; Consequences; Non; Random

This project aims to develop and apply novel statistical methods to quantify the effects on a large number of complex traits of two forms of non-random mating in humans, that is inbreeding and assortative mating. The innovation in this proposal lies in integrating multi-level phenotypes with next-generation sequencing data collected in more than half a million study participants. Expected outcomes of this research include advanced analytical methods to perform this integration and dissection of the biological consequences of non-random mating in humans at an unprecedented phenotypically detailed scale. The benefit of this project will be to identify new drivers of mate choice that can contribute to economic, health and social inequalities.

该项目旨在开发和应用新的统计方法来量化人类两种形式的非随机交配对大量复杂性状的影响，即近亲繁殖和替代交配。该提案的创新在于将多水平表型与从50多万研究参与者中收集的下一代测序数据相结合。这项研究的预期成果包括先进的分析方法，以前所未有的表型详细规模对人类非随机交配的生物学后果进行整合和解剖。该项目的好处是确定可能导致经济、健康和社会不平等的择偶新驱动因素。