MODULATION OF MEMORY

广泛的长期目标是：增加我们对基本知识的了解 存储和检索信息的心理生物学过程； 为加深我们对……的理解提供行为“准备” 记忆学记忆的病理学，包括由轻微的内环境平衡引起的 并将面向提取的记忆模型扩展到 厌恶动机行为的消亡领域，从而 获取可能与行为疗法相关的信息 恐惧症以及学习理论。的具体目标 评估记忆的各种调制主要有三个方面 建议的研究领域：1)分析和调查 忘记刺激属性的后果。这包括 广义干扰随时间变化的研究 培训与语境刺激；论“新学习”的潜在作用 在产生一定的提醒效果时；关于联觉的保持 提示；以及联合控制药物耐受性的变化。2) 健忘症患者记忆提取过程的研究。问题至 包括将记忆提取的控制权转移到 新线索；无法访问(但可恢复)的记忆的动态；以及 各种动态平衡紊乱与顺行的关系 健忘症。3)记忆检索图式在分析中的应用 令人厌恶的动机行为的消失。操纵器能设计成 在灭绝期间重新唤起对创伤插曲的记忆 暴露能增强消除恐惧吗？建议进行的研究包括 在反应预防期间，记忆重新激活的程度是不同的 (“泛滥”)在主动回避和在CS单独暴露期间 巴甫洛夫式的恐惧条件反射。这种方法提供了一种新的方向 消除恐惧动机反应的研究。

The broad, long-term objectives are: to increase our knowledge of basic psychobiological processes in storage and retrieval of information; to provide a behavioral "preparation" for furthering our understanding of the pathology of memory, including that resulting from minor homeostatic disturbances; and to extend a retrieval-oriented model of memory to the domain of the extinction of aversively motivated behaviors, thereby gaining information potentially relevant to behavior therapies for phobic disorders as well as to learning theory. The specific aims of assessing various modulations of memory are addressed in three major areas of proposed research: 1) Analysis and investigation of the consequences of the forgetting of stimulus attributes. This includes studies on time-dependent changes in generalized interference from training and contextual stimuli; on the potential role of "new learning" in producing certain reminder effects; on the retention of interoceptive cues; and o changes in the associative control over drug tolerance. 2) Investigation of aspects of retrieval processes in amnesia. Issues to be examined here include the transfer of control of memory retrieval to new cues; the dynamics of inaccessible (but recoverable) memory; and the relationship between various homeostatic disruption and anterograde amnesias. 3) Application of a memory retrieval schema to an analysis of extinction of aversively motivated behavior. Can manipulations designed to reactivate memory of a traumatic episode during an extinction exposure enhance the elimination of fear? Studies are proposed in which the level of memory reactivation is varied during response-prevention ("flooding") in active avoidance and during CS-alone exposure in Pavlovian fear conditioning. This approach provides a new direction for research of the elimination of fear motivated responding.