MODULATION OF MEMORY

记忆的调节

• 批准号: 2460311
• 负责人: DAVID RICCIO
• 金额: $ 11.32万
• 依托单位: KENT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-10-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2460311
• 关键词: animal developmental psychology; attribution; avoidance behavior; cues; discrimination learning; early experience; fear; homeostasis; laboratory rat; learning transfer; memory; memory disorders; motivation; neural information processing; psychobiology; stimulus /response; stimulus interval

The broad, long-term objectives are: to increase our knowledge of basic psychobiological processes in storage and retrieval of information; to provide a behavioral "preparation" for furthering our understanding of the pathology of memory, including that resulting from minor homeostatic disturbances; and to extend a retrieval-oriented model of memory to the domain of the extinction of aversively motivated behaviors, thereby gaining information potentially relevant to behavior therapies for phobic disorders as well as to learning theory. The specific aims of assessing various modulations of memory are addressed in three major areas of proposed research: 1) Analysis and investigation of the consequences of the forgetting of stimulus attributes. This includes studies on time-dependent changes in generalized interference from training and contextual stimuli; on the potential role of "new learning" in producing certain reminder effects; on the retention of interoceptive cues; and o changes in the associative control over drug tolerance. 2) Investigation of aspects of retrieval processes in amnesia. Issues to be examined here include the transfer of control of memory retrieval to new cues; the dynamics of inaccessible (but recoverable) memory; and the relationship between various homeostatic disruption and anterograde amnesias. 3) Application of a memory retrieval schema to an analysis of extinction of aversively motivated behavior. Can manipulations designed to reactivate memory of a traumatic episode during an extinction exposure enhance the elimination of fear? Studies are proposed in which the level of memory reactivation is varied during response-prevention ("flooding") in active avoidance and during CS-alone exposure in Pavlovian fear conditioning. This approach provides a new direction for research of the elimination of fear motivated responding.

广泛的，长期的目标是：增加我们的基本知识， 信息存储和检索的心理生物学过程; 为我们进一步理解 记忆的病理学，包括由轻微的自我平衡引起的 干扰;并将记忆的检索导向模型扩展到 领域的灭绝令人厌恶的动机行为，从而 获得与行为疗法潜在相关的信息， 恐惧症以及学习理论。 的具体目标 评估记忆的各种调制是在三个主要解决 建议的研究领域：1）分析和调查 忘记刺激属性的后果。 这包括 广义干扰随时间变化的研究 培训和环境刺激;关于"新学习"的潜在作用 在产生一定的提醒效果;对保留内感受性 提示;和o药物耐受性相关控制的变化。 （二） 健忘症检索过程方面的研究。 问题需要 在这里要检查的包括记忆检索的控制转移到 新的线索;不可访问（但可恢复）记忆的动态;以及 各种稳态破坏与顺行性 健忘症 3)应用记忆提取图式分析 消除令人厌恶的动机行为。 可以设计的操作 在大灭绝中重新激活创伤记忆 曝光增强消除恐惧？ 建议开展研究， 在响应阻止期间，存储器重新激活的水平是变化的 （"洪水"）在主动回避和CS单独暴露期间， 巴甫洛夫恐惧条件反射。 这种方法为以下方面提供了新的方向： 消除恐惧动机反应的研究。