MODULATION OF MEMORY

记忆的调节

• 批准号: 3486585
• 负责人: DAVID RICCIO
• 金额: $ 7.54万
• 依托单位: KENT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-10-01 至 1994-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3486585
• 关键词: animal developmental psychology; attribution; avoidance behavior; cues; discrimination learning; drug tolerance; early experience; fear; homeostasis; laboratory rat; learning transfer; memory; memory disorders; motivation; neural information processing; psychobiology; stimulus /response; stimulus interval

The broad, long-term objectives are: to increase our knowledge of basic psychobiological processes in storage and retrieval of information; to provide a behavioral "preparation" for furthering our understanding of the pathology of memory, including that resulting from minor homeostatic disturbances; and to extend a retrieval-oriented model of memory to the domain of the extinction of aversively motivated behaviors, thereby gaining information potentially relevant to behavior therapies for phobic disorders as well as to learning theory. The specific aims of assessing various modulations of memory are addressed in three major areas of proposed research: 1) Analysis and investigation of the consequences of the forgetting of stimulus attributes. This includes studies on time-dependent changes in generalized interference from training and contextual stimuli; on the potential role of "new learning" in producing certain reminder effects; on the retention of interoceptive cues; and o changes in the associative control over drug tolerance. 2) Investigation of aspects of retrieval processes in amnesia. Issues to be examined here include the transfer of control of memory retrieval to new cues; the dynamics of inaccessible (but recoverable) memory; and the relationship between various homeostatic disruption and anterograde amnesias. 3) Application of a memory retrieval schema to an analysis of extinction of aversively motivated behavior. Can manipulations designed to reactivate memory of a traumatic episode during an extinction exposure enhance the elimination of fear? Studies are proposed in which the level of memory reactivation is varied during response-prevention ("flooding") in active avoidance and during CS-alone exposure in Pavlovian fear conditioning. This approach provides a new direction for research of the elimination of fear motivated responding.

广泛的长期目标是： 增加我们对基本知识的了解 信息存储和检索的心理生物学过程；到 为进一步理解提供行为“准备” 记忆的病理学，包括由轻微的稳态引起的病理学 干扰；并将面向检索的记忆模型扩展到 厌恶动机行为消失的范围，从而 获取与行为疗法潜在相关的信息 恐惧症以及学习理论。 具体目标 评估记忆的各种调制主要分为三个方面 拟议研究领域： 1）分析和调查 忘记刺激属性的后果。 这包括 广义干扰随时间变化的研究 培训和情境刺激；论“新学习”的潜在作用 产生一定的提醒效果；关于内感受的保留 提示； o 对药物耐受性的联合控制的变化。 2） 对失忆症检索过程的各个方面进行调查。 问题至 这里要检查的包括将记忆检索的控制权转移到 新线索；不可访问（但可恢复）内存的动态；和 各种稳态破坏与顺行之间的关系 健忘症。 3) 记忆检索模式在分析中的应用 厌恶动机行为的消失。 可以设计操作吗 重新激活灭绝期间创伤事件的记忆 暴露增强消除恐惧？ 提出的研究其中 反应预防期间记忆重新激活的水平是不同的 （“洪水”）在主动回避和单独 CS 暴露期间 巴甫洛夫恐惧调节。 这一方法为 消除恐惧动机反应的研究。