AIDS CLINICAL TRIALS

该拨款请求(RFA)用于建立(继续) 成人临床试验方案，用于测试治疗糖尿病的药物 感染HIV-1的患者。审判的主旨将是 第二阶段/第三阶段议定书，以测试较新类型和组合的疗效 使用抗病毒药物来确定早期(通常是 无症状)，后来(免疫功能严重受损)HIV() 患者，以及那些对目前接受的治疗不耐受的人。在……里面 此外，新药物和要治疗的药物组合的方案 机会性感染、恶性肿瘤和相关的神经系统疾病 艾滋病患者将接受临床试验。 发展药理学：开发新的测试方法来测量 细胞内AZT水平了解乙酰化动力学的作用 在艾滋病患者中存在磺胺不耐受。 发育免疫学：细胞内可溶性细胞标记物的协调 流式细胞术检测细胞内HIV-1对病毒表达的激活作用 第24页。 发育寄生虫学：生长和聚合酶检测的研究 链式反应和微孢子虫病的治疗。

This grant request (RFA) is for the establishment (continuation) of an adult clinical trials program for the testing of drugs for the treatment of patients with HIV-1 infection. The major thrust of the trials will be phase II/III protocols to test efficacy of newer types and combinations of antiviral agents to determine the optimal approach to treat early (often asymptomatic), later, (with significant immunocompromised state) HIV (+) patients, as well as those intolerant to current accepted therapy. In addition, protocols for new agents and combinations of agents to treat opportunistic infections, malignancies, and neurological disease associated with AIDS will undergo clinical trials. DEVELOPMENTAL PHARMACOLOGY: Development of novel assays to measure the intracellular levels of AZT to understand the role of acetylation kinetics in sulfonamide intolerance in AIDS patients. DEVELOPMENTAL IMMUNOLOGY: Coordination of soluble cell markers of cellular activation with virus expression by Flow Cytometry of intracellular HIV-1 p24. DEVELOPMENTAL PARASITOLOGY: Study of the growth, detection by Polymerase Chain Reaction, and therapy of Microsporidiosis.