New Discoveries in Organic Synthesis Inspired by the Efficiency of Nature

受自然效率启发的有机合成新发现

• 批准号: DP200102964
• 负责人: A/Prof Jonathan George
• 金额: $ 29.49万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-06-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200102964
• 关键词: New; Discoveries; Organic; Synthesis; Inspired

Nature can assemble complex organic molecules from simple starting materials with apparent ease, but the laboratory synthesis of these natural products is very difficult. This project aims to mimic the way in which Nature constructs organic compounds and thus develop more efficient, greener synthetic processes in which there is a rapid build up of molecular complexity via “biomimetic” reactions. We will integrate this approach with modern methods of catalysis, including electrochemistry, photochemistry and biocatalysis. As a result, this work will expand the chemical space available to synthetic chemists working in the pharmaceutical industry. A further benefit is the training of the next generation of Australian synthetic chemists.

自然界可以很容易地从简单的起始材料组装复杂的有机分子，但这些天然产物的实验室合成是非常困难的。该项目旨在模仿大自然构建有机化合物的方式，从而开发更高效、更绿色的合成工艺，在这种工艺中，通过“仿生”反应快速建立分子复杂性。我们将把这种方法与现代催化方法相结合，包括电化学、光化学和生物催化。因此，这项工作将扩大制药行业合成化学家可用的化学空间。另一个好处是培训了下一代澳大利亚合成化学家。