Using natural products to inspire discoveries in synthesis and biosynthesis

利用天然产物激发合成和生物合成的发现

• 批准号: FT170100437
• 负责人: A/Prof Jonathan George
• 金额: $ 57.41万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-11-01 至 2021-10-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT170100437
• 关键词: Using; natural; products; inspire; discoveries

This project aims to understand the organic chemistry that occurs in the biosynthesis of unusual antibiotic natural products by marine microorganisms. In an interdisciplinary approach, proposed biosynthetic intermediates will be synthesised and screened against newly isolated enzymes from the microorganisms of interest. This will allow the elucidation of biosynthetic pathways, and aid the discovery of new chemoenzymatic reactivity that may be broadly useful in organic synthesis. Non-enzymatic, predisposed organic reactions will also be uncovered during the project. The benefit of this project will be an improvement in our ability to synthesise potential antibiotics using a combined synthetic organic and chemoenzymatic approach. This could lead to useful new antibiotics in the future.

该项目旨在了解海洋微生物生物合成不寻常的抗生素天然产物时发生的有机化学。在跨学科的方法中，将合成拟议的生物合成中间体，并针对来自感兴趣的微生物的新分离酶进行筛选。这将允许阐明生物合成途径，并有助于发现新的化学酶反应性，可能广泛用于有机合成。非酶促的、易发生的有机反应也将在项目期间被发现。该项目的好处将是提高我们使用有机合成和化学酶方法合成潜在抗生素的能力。这可能会在未来产生有用的新抗生素。