Predisposed organic synthesis inspired by the simplicty of nature

受自然简单启发的预先有机合成

• 批准号: DP160103393
• 负责人: A/Prof Jonathan George
• 金额: $ 24.78万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-09-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160103393
• 关键词: Predisposed; organic; synthesis; inspired; simplicty

The aim of this project is to use the simplicity and efficiency of biosynthesis to inspire the development of new strategies for the synthesis of whole families of related natural products with known antibiotic activity. Natural products with potent antibiotic properties are produced by microorganisms as a means of chemical defence. These complex molecules are biosynthesised from a limited set of simple biosynthetic building blocks via predisposed, complexity generating cascade reactions. The project aims to generate new lead compounds for the advancement of next-generation antibiotics. The synthesis of proposed biosynthetic intermediates would also allow enzymatic studies to help confirm the novel biosynthetic proposals.

该项目的目的是利用生物合成的简单性和效率来激发新策略的发展，以合成具有已知抗生素活性的相关天然产物的整个家族。具有强效抗生素特性的天然产物是由微生物作为化学防御手段产生的。这些复杂的分子是由一组有限的简单生物合成构建块通过预先处理的，复杂的级联反应产生的生物合成的。该项目旨在为下一代抗生素的发展创造新的先导化合物。提出的生物合成中间体的合成也将允许酶的研究，以帮助确认新的生物合成建议。