CV EFFECTS OF SLEEP RELATED BREATHING DISORDERS

我们的长期总体目标是收集基线数据和重复数据， 睡眠呼吸障碍的特征，重点是 呼吸事件和觉醒作为独立变量， 心血管风险本提案涉及收集 基准数据，预计该项目的延期将 允许后续行动。 我们这个项目的主要目的是收集数据， 关于SRBD和CV风险关系的几种假设中， 包括高血压和左心室肥大的发展。其次， 我们将测试睡眠中断和觉醒将是一个假设， 更好的睡眠相关呼吸障碍的严重程度的标志物， 因此，比参数更好地预测心血管发病率 从目前的呼吸监测技术。最后我们 建议检查和验证历史和活动记录的能力， 替代完整的多导睡眠图作为独立变量， 心血管结局的风险分析和 在初始队列中定义的患者组。验证这一方法 将极大地促进未来的纵向研究， 目前的数据库。

Our longterm overall goal is to collect both baseline data and repeated measures characterizing sleep disordered breathing, focusing on both respiratory events and arousal as independent variables in determining cardiovascular risk. The present proposal addresses collecting the baseline data, with the expectation that renewal of this project would allow the follow-up to be obtained. Our primary aim for this project is to collect data allowing the testing of several hypotheses about the relationship of SRBD and CV risk, including the development of hypertension and LV hypertrophy. Secondarily, we will test the hypothesis that sleep disruption and arousal will be a better marker of the severity of sleep related breathing disorders and therefore better predictors of cardiovascular morbidity than parameters derived from current respiratory monitoring techniques. Finally, we propose to examine and validate the ability of history and actigraphy to substitute for full polysomnography as the independent variables in analyses of risk for cardiovascular outcomes and in sequential testing of patient groups defined in the initial cohort. Validation of this approach would greatly facilitate future longitudinal studies which should evolve from the present data base.