EFFECT OF EXERCISE ON CORONARY DISEASE IN WOMEN

运动对女性冠心病的影响

• 批准号: 2227056
• 负责人: RITA F REDBERG
• 金额: $ 20.29万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-04-01 至 1998-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2227056
• 关键词: angiocardioultrasonography; angiography; atherosclerosis; cardiovascular disorder prevention; cardiovascular stress test; computed axial tomography; coronary disorder; disease /disorder proneness /risk; echocardiography; exercise; female; heart circulation; heart dimension /size; heart disorder diagnosis; high density lipoproteins; human subject; low density lipoprotein; mass screening; noninvasive diagnosis; postmenopause; sex hormones; women's health

The incidence of coronary artery disease in women over age 55 equals that of men, but mortality is higher. Relative to the number of studies of exercise and coronary disease in men, the role of exercise in women has been overlooked. This project will seek to define the role of habitual exercise in reducing the risk of coronary artery disease in women. These objectives will be realized by correlating levels of exercise with coronary disease and likely mediators of risk, such as distribution and concentration of lipoprotein species and sex hormones. These objectives will be accomplished by studying a group of women with a wide range of exercise fitness -- varying from sedentary individuals to triathletes, recruited from the ethnically diverse population of the San Francisco Bay area. Exercise fitness levels will be quantitated by maximal oxygen uptake (MVO2). Daily physical activities and exercise history as well as pack- year smoking history and percent ideal body weight will be determined by means of an exercise and health questionnaire and correlated to measured fitness levels(MVO2). The presence of critical coronary stenosis will be established by non- invasive testing: ultrafast computed tomography of the coronary tree and treadmill exercise echocardiography. Women who have evidence of coronary artery disease by either of these tests will have a transesophageal echocardiogram with coronary vasodilatation to quantitate proximal coronary stenosis and measure coronary vascular flow reserve. An additional aim of this project will be to correlate results of these non- invasive tests with quantitative angiographic and intravascular ultrasound characterization of coronary lesions. This project is designed to help reduce the high morbidity and mortality of cardiovascular disease in post-menopausal women by defining an optimal level of regular habitual exercise that offers cardiovascular protection. This level will be expressed in terms of everyday activities or moderate intensity exercise so that it is wide applicable.

55岁以上女性的冠状动脉疾病发病率相当于 但死亡率更高。相对于研究的数量， 运动与男性冠心病，运动对女性的作用有 被忽视了。这个项目将寻求定义习惯性的角色 运动在降低女性冠状动脉疾病风险方面的作用。这些 目标的实现将通过将运动水平与 冠心病和可能的风险介体，如分布和 脂蛋白种类和性激素的浓度。这些目标 将通过研究一组拥有广泛的 运动健身--从久坐不动的个人到铁人三项运动员， 从旧金山湾不同种族的人群中招募 区域。运动健康水平将通过最大摄氧量来量化。 (MVO2)。日常体育活动和运动史，以及背包- 年吸烟史和理想体重百分比由以下因素决定 运动与健康问卷的均值及其与测量结果的相关性 体能水平(MVO2)。 严重冠状动脉狭窄的存在将由非 侵入性测试：冠状动脉树和冠状动脉的超高速CT 跑步机运动超声心动图。有冠心病证据的女性 这两种测试中的任何一种动脉疾病都将通过食道 超声心动图冠状动脉近端扩张定量 冠状动脉狭窄和测量冠脉血流储备。一个 该项目的其他目标将是将这些非 定量血管造影和血管内超声的侵入性测试 冠脉病变的特征。 该项目旨在帮助降低高发病率和死亡率。 通过定义最佳的绝经后妇女心血管疾病 提供心血管保护的定期习惯性运动的水平。 这一水平将以日常活动或适度活动的形式表达 使其具有广泛的适用性。