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EFFECT OF EXERCISE ON CORONARY DISEASE IN WOMEN

运动对女性冠心病的影响

基本信息

批准号：
2392722
负责人：
RITA F REDBERG
金额：
$ 22.17万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-04-01 至 1999-03-31
项目状态：
已结题

项目摘要

The incidence of coronary artery disease in women over age 55 equals that of men, but mortality is higher. Relative to the number of studies of exercise and coronary disease in men, the role of exercise in women has been overlooked. This project will seek to define the role of habitual exercise in reducing the risk of coronary artery disease in women. These objectives will be realized by correlating levels of exercise with coronary disease and likely mediators of risk, such as distribution and concentration of lipoprotein species and sex hormones. These objectives will be accomplished by studying a group of women with a wide range of exercise fitness -- varying from sedentary individuals to triathletes, recruited from the ethnically diverse population of the San Francisco Bay area. Exercise fitness levels will be quantitated by maximal oxygen uptake (MVO2). Daily physical activities and exercise history as well as pack- year smoking history and percent ideal body weight will be determined by means of an exercise and health questionnaire and correlated to measured fitness levels(MVO2). The presence of critical coronary stenosis will be established by non- invasive testing: ultrafast computed tomography of the coronary tree and treadmill exercise echocardiography. Women who have evidence of coronary artery disease by either of these tests will have a transesophageal echocardiogram with coronary vasodilatation to quantitate proximal coronary stenosis and measure coronary vascular flow reserve. An additional aim of this project will be to correlate results of these non- invasive tests with quantitative angiographic and intravascular ultrasound characterization of coronary lesions. This project is designed to help reduce the high morbidity and mortality of cardiovascular disease in post-menopausal women by defining an optimal level of regular habitual exercise that offers cardiovascular protection. This level will be expressed in terms of everyday activities or moderate intensity exercise so that it is wide applicable.

55岁以上女性的冠状动脉疾病发病率等于但死亡率更高。相对于运动与冠心病在男性中的作用，运动对女性有被忽视了这个项目将寻求定义习惯的作用，运动可以降低女性患冠状动脉疾病的风险。这些目标将通过将运动水平与冠状动脉疾病和可能的风险介质，如分布和脂蛋白种类和性激素的浓度。这些目标将通过研究一组具有广泛的运动健身--从久坐的人到铁人三项运动员，从旧金山弗朗西斯科湾种族多样的人群中招募区运动健身水平将通过最大摄氧量进行量化（MVO 2）。日常体育活动和运动史以及包装- 年吸烟史和理想体重百分比将通过以下方法确定运动和健康问卷的手段并与测量的相关性健身水平（MVO 2）。临界冠状动脉狭窄的存在将通过非- 侵入性测试：冠状动脉树的超快速计算机断层扫描，踏车运动超声心动图有冠心病证据的女性通过这些测试中的任何一种，动脉疾病都将有一个经食道的超声心动图伴冠状血管舒张以定量近端冠状动脉狭窄和测量冠状动脉血管血流储备。一个该项目的另一个目标是将这些非定量血管造影和血管内超声侵入性检查冠状动脉病变的特征。该项目旨在帮助降低高发病率和死亡率绝经后妇女的心血管疾病，通过定义一个最佳有规律的习惯性运动水平，提供心血管保护。这一水平将表示在日常活动方面或中度强度大，适用范围广。