NEUROTOXICOLOGY OF SUPERFUND CHEMICALS

SUPERFUND 化学品的神经毒理学

• 批准号: 3104532
• 负责人: HERBERT E LOWNDES
• 金额: $ 111.48万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1995-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3104532
• 关键词: environmental toxicology; industrial waste; lead poisoning; neurotoxins; nonwater solvent

This application, prepared in response to RFA ES-91-02, will address the need for additional studies on neurological and behavioral aspects of chemicals commonly found in Superfund dumpsites. Research focus within the eight multidisciplinary projects of the program will be achieved by addressing specifically the neurotoxicity of selected solvents (trichloroethylene, monochloroacetic acid, related halogenated hydrocarbons) and metals (lead). Projects have been designed to examine: 1. the hydrogeology of solvents. 2. the neurotoxicity of solvents at the biochemical/cellular levels. 3. the neurotoxicity of lead on developing and adult neuronal systems. 4. the ecological and human neurobehavioral responses to lead and solvents. 5. engineering approaches to the biological treatment of Superfund contaminants. These studies will be conducted by members of the Environmental and Occupational Health Sciences Institute, a research institute comprising investigators from Rutgers, The State University of New Jersey and R.W. Johnson Medical School, The University of Medicine and Dentistry of New Jersey.

本申请是根据RFA ES-91-02编写的，将解决以下问题