CONSEQUENCES OF PROXIMAL GIANT AXON FORMATIONS
CONSEQUENCES OF PROXIMAL GIANT AXON FORMATIONS
批准号:
3406658
负责人:
HERBERT E LOWNDES
金额:
$20.14万
依托单位国家:
美国
项目类别:
财政年份:
1985
资助国家:
美国
项目状态:
已结题
起止时间:
1985-07-01 至 1993-12-31
关键词:
acrylamides cats computer data analysis dosage doxorubicin drug adverse effect electron microscopy electrophysiology histopathology microscopy motor neurons muscle contraction neural degeneration neuromuscular transmission neuronal transport neurotoxins occupational hazard peripheral nervous system disorders radiotracer sensorimotor system spinal nerves stretch receptors
中文摘要
周围感觉神经末梢似乎比它们的运动更敏感
相当于某些药物的神经毒性作用。脑部的一个病变
这些神经的脊髓终末,与周围神经的终末相对应
终端,将导致本体感觉信息的不正确整合
在脊髓突触上,从而使周围的缺陷变得复杂。初级传入
将对患有神经疾病的猫的终末功能进行调查
丙烯酰胺或阿霉素。具体地说,突触服务于节段性反射
背侧脊髓小脑束的起源细胞将是
电生理学评估。这些数据将与那些具有
试图确定脊髓的贡献的形态学研究
缺陷会导致周围神经病的临床体征。
英文摘要
Peripheral sensory nerve terminals appear more susceptible than their motor
counterparts to the neurotoxic effects of certain agents. A lesion in the
spinal cord termination of these nerves, corresponding to that in the peripheral
terminals, would result in incorrect integration of proprioceptive information
at spinal synapses and thus compound the peripheral defect. Primary afferent
terminal function will be investigated in cats with neuropathies included by
acrylamide or doxorubicin. Specifically, synapses subserving segmental reflexes
and the cells of origin of the dorsal spinocerebellar tracts will be
electrophysiologically evaluated. These data will be correlated with those with
morphological studies in an attempt to ascertain the contribution of spinal cord
defects make to the clinical signs of the peripheral neuropathies.
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Biochemical studies of acrylamide neuropathy.
丙烯酰胺神经病的生化研究。
DOI:
--
发表时间:
1985
期刊:
Neurotoxicology
影响因子:
3.4
作者:
[Howland,RD]
通讯作者:
Howland,RD
Electrophysiological investigation of IDPN neuropathy--initial studies.
IDPN 神经病的电生理学研究——初步研究。
DOI:
--
发表时间:
1985
期刊:
Neurotoxicology
影响因子:
3.4
作者:
[Lowndes,HE, Delio,DA, Gold,BG]
通讯作者:
Gold,BG
Electrophysiological investigation of beta, beta'-iminodipropionitrile neurotoxicity: monosynaptic reflexes and recurrent inhibition.
β,β-亚氨基二丙腈神经毒性的电生理学研究:单突触反射和反复抑制。
DOI:
--
发表时间:
1984
期刊:
Neurotoxicology
影响因子:
3.4
作者:
[Gold,BG, Lowndes,HE]
通讯作者:
Lowndes,HE
Occurrence of lipofuscin pigment granules and "dense microspheres" in the spinal cord of young cats treated with beta,beta'-iminodipropionitrile (IDPN).
用 β,β-亚氨基二丙腈 (IDPN) 治疗的幼猫脊髓中出现脂褐素色素颗粒和“致密微球”。
DOI:
--
发表时间:
1988
期刊:
Histology and histopathology
影响因子:
2
作者:
[Fiori,MG, Lowndes,HE]
通讯作者:
Lowndes,HE
Inhibition of glyceraldehyde-3-phosphate dehydrogenase in tissues of the rat by acrylamide and related compounds.
丙烯酰胺和相关化合物对大鼠组织中甘油醛-3-磷酸脱氢酶的抑制作用。
DOI:
--
发表时间:
1985
期刊:
Neurotoxicology
影响因子:
3.4
作者:
[Vyas,I, Lowndes,HE, Howland,RD]
通讯作者:
Howland,RD
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CONSEQUENCES OF PROXIMAL GIANT AXON FORMATIONS
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CONSEQUENCES OF PROXIMAL GIANT AXON FORMATIONS
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批准号:3406656
-
项目类别:
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CONSEQUENCES OF PROXIMAL GIANT AXON FORMATIONS
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CONSEQUENCES OF PROXIMAL GIANT AXON FORMATIONS
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CONSEQUENCES OF PROXIMAL GIANT AXON FORMATIONS
-
批准号:3406657
-
项目类别:
-
资助金额:$19.48万
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财政年份:1985
-
负责人:HERBERT E LOWNDES
-
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CONSEQUENCES OF PROXIMAL GIANT AXON FORMATIONS
-
批准号:3406652
-
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-
资助金额:$16.82万
-
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-
负责人:HERBERT E LOWNDES
-
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