CONSEQUENCES OF PROXIMAL GIANT AXON FORMATIONS

近端巨大轴突形成的后果

• 批准号: 3406654
• 负责人: HERBERT E LOWNDES
• 金额: $ 16.93万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-07-01 至 1992-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3406654
• 关键词: acrylamides; cats; computer data analysis; dosage; doxorubicin; drug adverse effect; electron microscopy; electrophysiology; histopathology; microscopy; motor neurons; muscle contraction; neural degeneration; neuromuscular transmission; neurotoxins; occupational hazard; peripheral nervous system disorders; radiotracer; sensorimotor system; spinal nerves; stretch receptors

Peripheral sensory nerve terminals appear more susceptible than their motor counterparts to the neurotoxic effects of certain agents. A lesion in the spinal cord termination of these nerves, corresponding to that in the peripheral terminals, would result in incorrect integration of proprioceptive information at spinal synapses and thus compound the peripheral defect. Primary afferent terminal function will be investigated in cats with neuropathies included by acrylamide or doxorubicin. Specifically, synapses subserving segmental reflexes and the cells of origin of the dorsal spinocerebellar tracts will be electrophysiologically evaluated. These data will be correlated with those with morphological studies in an attempt to ascertain the contribution of spinal cord defects make to the clinical signs of the peripheral neuropathies.

周围感觉神经末梢似乎比它们的运动神经更容易受到影响