NEUROTOXICOLOGY OF SUPERFUND CHEMICALS

SUPERFUND 化学品的神经毒理学

• 批准号: 3104533
• 负责人: HERBERT E LOWNDES
• 金额: $ 108.22万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1995-03-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3104533
• 关键词: environmental toxicology; industrial waste; lead poisoning; neurotoxins; nonwater solvent

This application, prepared in response to RFA ES-91-02, will address the need for additional studies on neurological and behavioral aspects of chemicals commonly found in Superfund dumpsites. Research focus within the eight multidisciplinary projects of the program will be achieved by addressing specifically the neurotoxicity of selected solvents (trichloroethylene, monochloroacetic acid, related halogenated hydrocarbons) and metals (lead). Projects have been designed to examine: 1. the hydrogeology of solvents. 2. the neurotoxicity of solvents at the biochemical/cellular levels. 3. the neurotoxicity of lead on developing and adult neuronal systems. 4. the ecological and human neurobehavioral responses to lead and solvents. 5. engineering approaches to the biological treatment of Superfund contaminants. These studies will be conducted by members of the Environmental and Occupational Health Sciences Institute, a research institute comprising investigators from Rutgers, The State University of New Jersey and R.W. Johnson Medical School, The University of Medicine and Dentistry of New Jersey.

本申请是根据RFA ES-91-02编写的，将解决 需要进一步研究神经和行为方面的 超级基金垃圾场常见的化学物质 研究重点在 该计划的八个多学科项目将通过以下方式实现： 特别针对选定溶剂的神经毒性 （三氯乙烯、一氯乙酸、相关卤代 碳氢化合物）和金属（铅）。 这些项目旨在审查： 1.溶剂的水文地质学 2.溶剂在生物化学/细胞水平上的神经毒性。 3.铅对发育和成年神经系统的神经毒性。 4.生态学和人类神经行为对铅和溶剂的反应。 5.超级基金生物处理的工程方法 污染物。 这些研究将由环境及 职业健康科学研究所，一个研究所，包括 来自罗格斯大学、新泽西的州立大学和R.W. 纽约医学和牙科大学约翰逊医学院 球衣是个什么鬼