COGNITIVE & NEUROANATOMIC STUDIES OF ACQUIRED DYSLEXIAS

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• 批准号: 2268051
• 负责人: BARRY GORDON
• 金额: $ 27.57万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-12-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2268051
• 关键词: aphasia; cognition; epilepsy; human subject; longitudinal human study; magnetic resonance imaging; neuroanatomy; neurosurgery; partial seizure; postoperative complications; preoperative state; reading; reading disorder

This is a prospective, within- and between-subjects study of the functional and the neuroanatomic bases for acquired disorders of reading and related functions, such as naming. The opportunity for this study occurs because patients having medically-necessary surgical resections of cerebral tissue in certain brain regions sometimes (about 15-25%) develop problems with reading or related functions that persist for weeks to months. Subjects will be tested before surgery for the status or relevant functions as stipulated by current theories of reading. Relevant clinical data on their functional-neuroanatomic organization will also be collected. They will then be studied extensively at frequent intervals after surgery, and also will have high-quality MRI scanning (early and late) for neuroanatomic analyses, including 3D reconstructions. This subjects with deficits in reading and related functions offer an opportunity for a sensitive, within-subjects identification of which specific functional impairments underlie their observed deficits. The subjects without overt deficits after surgery will serve as case controls for the significance of any identified functional deficits. The neuroanatomic association of the observed deficits will also be determined, by several approaches: within-subjects correlations: comparisons across subjects by deficit; and comparisons across subjects by site(s) of structural damage. As subjects with deficits improve over time, they will have additional intensive testing to determine whether the underlying component processes are changing quantitatively or qualitatively, using both within-subjects and between- subjects comparisons. These data will therefore provide further tests of the basis for their disorders of reading and related functions, and of the neuroanatomic correlates of the underlying processes. Research on this unique patient population is expected to provide a highly detailed specification of the underlying processing deficits responsible for impairments in reading and related functions in these individuals, and of the neuroanatomic associations of any specific processing deficits. Because it is a prospective study of patients with surgical lesions, deficits and neuroanatomic associations will be delineated with greater precision, less confounding by compensatory mechanisms, and less reporting bias than in previous studies. The data obtained should also be valuable for understanding how reading and related functions are normally accomplished by the brain.

这是一项前瞻性的、受试者内部和受试者之间的研究 获得性阅读障碍的功能和神经解剖学基础 以及相关功能，如命名。这项研究的机会 发生是因为患者接受了医学上必要的手术切除 有时某些脑区的脑组织(约15-25%) 出现持续数周的阅读或相关功能问题 长达几个月。受试者将在手术前接受状态测试或 现行阅读理论所规定的相关功能。 其功能神经解剖组织的相关临床资料 也将被收集。然后将经常对它们进行广泛的研究 手术后间隔时间，也将有高质量的MRI扫描 (早期和晚期)用于神经解剖分析，包括3D 重建。本课题与阅读障碍及相关 函数提供了一个敏感的、在主题内的机会 确定哪些特定的功能障碍是其基础 观察到的缺陷。手术后无明显缺陷的受试者 将作为病例对照，以确定任何已确定的 功能缺陷。被观察者的神经解剖学联系 赤字也将通过几种方法来确定：受试者内部 相关性：不同研究对象之间的差距比较；以及比较 按场地(S)划分的结构损坏的所有对象。作为受试者 赤字会随着时间的推移而改善，他们将进行额外的密集测试 确定基础组件进程是否正在更改 在数量上或质量上，使用对象内和对象之间的- 受试者比较。因此，这些数据将提供进一步的测试 他们的阅读障碍和相关功能障碍的基础是什么？ 潜在突起的神经解剖学关联。 对这一独特患者群体的研究有望提供一种 基础处理缺陷的非常详细的规范 对阅读障碍和相关功能障碍负责 个体以及任何特定个体的神经解剖学联系 处理赤字。因为这是一项前瞻性研究，研究对象为 手术损伤、缺陷和神经解剖学联系将是 更精确地描绘，通过补偿减少混淆 机制，与以前的研究相比，报告偏差更小。数据 也应该对理解阅读和 相关功能通常由大脑完成。