CIRCANNUAL RHYTHMS OF ENERGY BALANCE AND BEHAVIOR

能量平衡和行为的周期性节奏

• 批准号: 2268783
• 负责人: JOHN G DARK
• 金额: $ 18.56万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2268783
• 关键词: adipose tissue; arousal; bioenergetics; bioperiodicity; blood chemistry; body weight; brown fat; experimental brain lesion; free fatty acids; glucose; hibernation; hypothermia; lipolysis; oxidation; squirrel; telemetry; vagotomy

The overall goal is to delineate the interactions among neuroendocrine mechanisms that regulate energy balance, hibernation, and reproduction. Circannual rhythms of each of these behaviors have been well described in the golden-mantled ground squirrel (Spermophilus lateralis), the model species in all experiments. Specific aims include: 1) characterizing metabolic fuel utilization during deep torpor and arousal; 2) determining the role of metabolic fuel availability in controlling hibernation bout length; 3) evaluating adipose tissue function at low temperatures of deep torpor; 4) specification of neural mechanisms that control metabolic fuel utilization during deep torpor and arousal; 5) describing the effect of size of adipose tissue stores on duration of torpor and frequency of arousal; 6) evaluating the relation between energy reserves and availability of specific metabolic fuels. Body weight related problems are a major medical concern. Much remains that we do not understand about the physiological mechanisms underlying food intake and body fat regulation. Deciphering how metabolic fuels are stored and mobilized in a model system like the golden-mantled ground squirrel could provide important insights into the regulation of these processes for mammals in general and humans in particular. Similarly, a better understanding of the mechanisms of reversible hypothermia is of potential medical import. The reduced metabolism, blood flow, etc. coincident with hypothermia may be very beneficial during many types of major surgery. Little is known at this time of the mechanism that allows ground squirrels and other hibernators to undergo prolonged hypothermia which is lethal to humans and other mammals. The proposed research addresses fundamental questions in regulatory biology and, thereby, affords the opportunity of establishing general principles applicable to all mammals.

总体目标是描述神经内分泌之间的相互作用。 调节能量平衡、冬眠和繁殖的机制。 每种行为的周年节律都在 金毛地松鼠(Spermophilus Lateralis)，模型 所有实验中的物种。具体目标包括：1)塑造 深度昏迷和觉醒时代谢燃料的利用；2)测定 代谢燃料的可获得性在控制冬眠中的作用 3)深部低温下脂肪组织功能的评价 麻木；4)控制新陈代谢燃料的神经机制规范 在深度麻木和觉醒期间的使用；5)描述 脂肪组织储存的大小与麻木持续时间和频率有关 唤醒；6)评估能量储备与 特定代谢燃料的可用性。 与体重相关的问题是一个主要的医学问题。剩下的很多 我们对其背后的生理机制并不了解 食物摄入量和体脂调节。解读新陈代谢燃料是如何 储存和动员在一个模型系统中，就像金色的披肩土地 松鼠可以为这些行为的监管提供重要的见解 一般哺乳动物，特别是人类的加工过程。类似地，一个 更好地理解可逆性低温的机制是 潜在的医疗进口。新陈代谢减少、血流减少等。 在许多类型的心力衰竭中，联合低温可能非常有益。 大手术。目前，人们对这种机制知之甚少 地松鼠和其他冬眠动物将经历长期低温 这对人类和其他哺乳动物都是致命的。拟议的研究 解决了调控生物学中的基本问题，从而为 制定适用于所有人的一般原则的机会 哺乳动物。