Annual Rhythms of Energy Balance and Behavior

能量平衡和行为的年度节奏

• 批准号: 7729059
• 负责人: JOHN G DARK
• 金额: $ 32.92万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-16 至 2011-05-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7729059
• 关键词: Ablation; Affect; Agonist; Animals; Attention; Behavior; Body Temperature; Body fat; Brown Fat; Control Groups; Critiques; Data; Development; Diffusion; Eating; Energy Metabolism; Figs - dietary; Food; Goals; Hamsters; Hypothalamic structure; Ibotenic Acid; Injection of therapeutic agent; Leptin; Lesion; Lipectomy; Medial; Mesocricetus auratus; Modeling; Mus; Nature; Neurons; Neuropeptide Y Receptor; Peptides; Peripheral; Phodopus sungorus; Photoperiod; Play; Preoptic Areas; Principal Investigator; Progress Reports; Reaction Time; Regulation; Reproduction; Research Methodology; Role; Siberian Hamster; Site; Structure of nucleus infundibularis hypothalami; Temperature; Testing; Time; Update; Work; base; energy balance; hindbrain; in vivo; induced hypothermia; leptin receptor; mouse leptin receptor; natural hypothermia; neuromechanism; neuropeptide Y; neurotoxic; paraventricular nucleus; programs; receptor; research study; response

DESCRIPTION (provided by applicant): The overall goal is to characterize the role that body fat reserves and hypothalamic peptide mechanisms, especially neuropeptide Y (NPY), play in controlling daily torpor. Daily torpor is an extreme form of temperature regulation that evolved to help animals contend with limited food availability by uniquely reducing energy expenditure. The central and peripheral neural mechanisms integrating overall energy balance and torpor will be explored. Annual rhythms of food intake and body mass, reproduction, and daily torpor are well documented in the Siberian hamster (Phodopus sungorus), the model species in all experiments. Specific aims include: 1) contrasting the effects of direct intra-medial preoptic area (MPOA) injections of NPY on body temperature, specifically its ability to induce torpor and affect the timing of changes in brown adipose tissue temperature vs. body temperature; 2) developing an anatomical understanding of the distribution of NPY receptor subtypes in the Siberian hamster hypothalamus; 3) comparing and contrasting NPY receptor agonist activation and antagonist inhibition of NPY receptor sites in the MPOA on torpor induction; 4) evaluating the necessity of the MPOA for both induced (NPY & 2DG) and natural torpor using neuron-specific neurotoxic lesions; 5) comparing and contrasting effects of direct injections of NPY and NPY receptor agonists into the paraventricular nucleus of the hypothalamus on interscapular brown adipose tissue temperature (and body temperature).

描述（由申请人提供）：总体目标是表征体脂储备和下丘脑肽机制，特别是神经肽Y（NPY）在控制日常麻木中的作用。日常休眠是一种极端的温度调节形式，通过独特的减少能量消耗来帮助动物应对有限的食物供应。将探讨整合整体能量平衡和麻痹的中枢和外周神经机制。食物摄入量和体重，繁殖，和每日的麻木的年度节奏在西伯利亚仓鼠（Photopus sungorus），在所有实验的模式物种有很好的记录。具体目标包括：1）对比直接内侧视前区（MPOA）注射NPY对体温的影响，特别是其诱导麻痹和影响棕色脂肪组织温度与体温变化的时间的能力; 2）发展对西伯利亚仓鼠下丘脑中NPY受体亚型分布的解剖学理解; 3）比较和对比MPOA中NPY受体激动剂激活和拮抗剂抑制NPY受体位点对麻痹诱导的影响;（NPY和2DG）和自然麻痹使用神经元特异性神经毒性损伤; 5）比较和对比将NPY和NPY受体激动剂直接注射到下丘脑的室旁核中对肩胛间棕色脂肪组织温度（和体温）的影响。

项目成果

Role of area postrema in control of torpor in Siberian hamsters.

后区在控制西伯利亚仓鼠麻木状态中的作用。

• DOI: 10.1152/ajpregu.2000.279.2.r591
• 发表时间: 2000
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: Bae,HH;Stamper,JL;Heydorn,EC;Zucker,I;Dark,J
• 通讯作者: Dark,J

Olfactory bulb removal lengthens the period of circannual rhythms and disrupts hibernation in golden-mantled ground squirrels.

去除嗅球会延长金毛地松鼠的昼夜节律，并扰乱冬眠。

• DOI: 10.1016/0006-8993(93)90765-f
• 发表时间: 1993
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Ruby,NF;Zucker,I;Licht,P;Dark,J
• 通讯作者: Dark,J

Melatonin influences sex-specific prenatal mortality in meadow voles.

褪黑激素影响草甸田鼠的性别特异性产前死亡率。

• DOI: 10.1095/biolreprod51.5.873
• 发表时间: 1994
• 期刊: Biology of reproduction
• 影响因子: 3.6
• 作者: Gorman,MR;Ferkin,MH;Dark,J
• 通讯作者: Dark,J

Monosodium glutamate-induced arcuate nucleus damage affects both natural torpor and 2DG-induced torpor-like hypothermia in Siberian hamsters.

• DOI: 10.1152/ajpregu.00387.2007
• 发表时间: 2008
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: K. Pelz;D. Routman;Joseph R. Driscoll;L. Kriegsfeld;J. Dark

ICV NPY Y1 receptor agonist but not Y5 agonist induces torpor-like hypothermia in cold-acclimated Siberian hamsters.

ICV NPY Y1 受体激动剂而非 Y5 激动剂会在冷适应的西伯利亚仓鼠中诱导类似冬眠的低温。

• DOI: 10.1152/ajpregu.00790.2006
• 发表时间: 2007
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: Pelz,KimberlyM;Dark,John
• 通讯作者: Dark,John