ANNUAL RHYTHMS OF ENERGY BALANCE AND BEHAVIOR

年度能量平衡和行为节奏

• 批准号: 2519950
• 负责人: JOHN G DARK
• 金额: $ 18.47万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-16 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2519950
• 关键词: bioenergetics; bioperiodicity; blood chemistry; blood glucose; body temperature regulation; brain stem; circadian rhythms; experimental brain lesion; hamsters; hibernation; hyperprolactinemia; hypothalamus; hypothermia; lactation; neuroendocrine system; reproduction; telemetry; testosterone

DESCRIPTION (adapted from investigator's abstract): The overall goal of this project is to characterize the neuroendocrine mechanisms that underlie daily torpor, an extreme form of temperature regulation that evolved to help animals contend with limited food availability. The relation of torpor to overall energy balance and reproduction will be explored. Annual rhythms of daily torpor are well documented in the Siberian hamster (Phodopus sungorus), the model species in all experiments. Specific aims include: (1) determining the role of caudal brainstem and hypothalamic mechanisms in initiation of daily torpor; (2) specifying possible central neural systems activated during initiation of torpor with c-fos; (3) identifying the role of endogenous glucose during the initiation of torpor behavior; (4) evaluating the role of peripheral neural mechanisms in the initiation of torpor; (5) characterizing the neural mechanisms underlying testosterone inhibition of torpor; and (6) examining the counteractive nature of lactation and hyperprolactinemia on torpor.

描述（改编自研究者摘要）：总体目标 这个项目是为了描述神经内分泌机制， 每日的麻木，一种极端的温度调节形式， 动物与有限的食物供应作斗争。 迟钝与 将探讨总体能量平衡和繁殖。 年节律 在西伯利亚仓鼠（Photopus）中，每天都有很好的记录 sungorus），所有实验中的模式物种。 具体目标包括： (1)确定尾侧脑干和下丘脑机制在 日常麻木的开始;（2）指定可能的中枢神经系统 在c-fos启动休眠过程中激活;（3）确定c-fos在休眠过程中的作用 内源性葡萄糖在麻痹行为的启动过程中;（4） 评估外周神经机制在启动 （5）表征睾酮的神经机制 抑制迟钝;和（6）检查的反作用性质， 哺乳和高催乳素血症。