ANNUAL RHYTHMS OF ENERGY BALANCE AND BEHAVIOR

描述(改编自调查员摘要)：总体目标 这个项目是为了描述神经内分泌机制的特征。 每日麻木，一种极端的体温调节形式，进化出有助于 动物们正在与有限的食物供应作斗争。麻木与 将探索总体能量平衡和再生产。一年一度的节奏 西伯利亚仓鼠(Photopus)每天的麻木状态有很好的记录 太阳大猩猩)，是所有实验的模式物种。具体目标包括： (1)确定尾侧脑干和下丘脑机制在 日常麻木的开始；(2)指定可能的中枢神经系统 在使用c-fos启动昏迷期间激活；(3)识别角色 在麻木行为开始时的内源性葡萄糖；(4) 评估外周神经机制在启动脑电活动中的作用 麻木；(5)描述睾丸激素的神经机制 对麻木的抑制；以及(6)检查 哺乳和高催乳素血症麻木。

DESCRIPTION (adapted from investigator's abstract): The overall goal of this project is to characterize the neuroendocrine mechanisms that underlie daily torpor, an extreme form of temperature regulation that evolved to help animals contend with limited food availability. The relation of torpor to overall energy balance and reproduction will be explored. Annual rhythms of daily torpor are well documented in the Siberian hamster (Phodopus sungorus), the model species in all experiments. Specific aims include: (1) determining the role of caudal brainstem and hypothalamic mechanisms in initiation of daily torpor; (2) specifying possible central neural systems activated during initiation of torpor with c-fos; (3) identifying the role of endogenous glucose during the initiation of torpor behavior; (4) evaluating the role of peripheral neural mechanisms in the initiation of torpor; (5) characterizing the neural mechanisms underlying testosterone inhibition of torpor; and (6) examining the counteractive nature of lactation and hyperprolactinemia on torpor.