CIRCANNUAL RHYTHMS OF ENERGY BALANCE AND BEHAVIOR

能量平衡和行为的周期性节奏

• 批准号: 3417742
• 负责人: JOHN G DARK
• 金额: $ 16.15万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 1996-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3417742
• 关键词: adipose tissue; arousal; bioenergetics; bioperiodicity; blood chemistry; body weight; brown fat; experimental brain lesion; free fatty acids; glucose; hibernation; hypothermia; lipolysis; oxidation; squirrel; telemetry; vagotomy

The overall goal is to delineate the interactions among neuroendocrine mechanisms that regulate energy balance, hibernation, and reproduction. Circannual rhythms of each of these behaviors have been well described in the golden-mantled ground squirrel (Spermophilus lateralis), the model species in all experiments. Specific aims include: 1) characterizing metabolic fuel utilization during deep torpor and arousal; 2) determining the role of metabolic fuel availability in controlling hibernation bout length; 3) evaluating adipose tissue function at low temperatures of deep torpor; 4) specification of neural mechanisms that control metabolic fuel utilization during deep torpor and arousal; 5) describing the effect of size of adipose tissue stores on duration of torpor and frequency of arousal; 6) evaluating the relation between energy reserves and availability of specific metabolic fuels. Body weight related problems are a major medical concern. Much remains that we do not understand about the physiological mechanisms underlying food intake and body fat regulation. Deciphering how metabolic fuels are stored and mobilized in a model system like the golden-mantled ground squirrel could provide important insights into the regulation of these processes for mammals in general and humans in particular. Similarly, a better understanding of the mechanisms of reversible hypothermia is of potential medical import. The reduced metabolism, blood flow, etc. coincident with hypothermia may be very beneficial during many types of major surgery. Little is known at this time of the mechanism that allows ground squirrels and other hibernators to undergo prolonged hypothermia which is lethal to humans and other mammals. The proposed research addresses fundamental questions in regulatory biology and, thereby, affords the opportunity of establishing general principles applicable to all mammals.

总体目标是描述神经内分泌之间的相互作用 调节能量平衡、冬眠和繁殖的机制。 这些行为的周期性节律已在 金披地松鼠（Spermophilus Lateris），模型 所有实验中的物种。 具体目标包括：1）表征 深度麻木和觉醒期间代谢燃料的利用； 2）确定 代谢燃料可用性在控制冬眠发作中的作用 长度; 3）评估深部低温下的脂肪组织功能 麻木; 4）控制代谢燃料的神经机制的规范 在深度麻木和觉醒期间使用； 5）描述效果 脂肪组织储存的大小与麻木持续时间和麻木频率有关 唤醒； 6）评估能量储备与能量储备之间的关系 特定代谢燃料的可用性。 体重相关问题是一个主要的医学问题。 还剩下很多 我们不了解其背后的生理机制 食物摄入量和体脂调节。 解读代谢燃料是如何产生的 存储和调动在一个模型系统中，就像金色的大地一样 松鼠可以为这些监管提供重要的见解 一般哺乳动物，特别是人类的过程。 同样，一个 更好地了解可逆性低温的机制至关重要 潜在的医疗进口。 新陈代谢、血流量等减少。 在许多类型的情况下，与低温同时发生可能非常有益 大手术。 目前对允许的机制知之甚少 地松鼠和其他冬眠动物会经历长时间的低温 这对人类和其他哺乳动物来说是致命的。 拟议的研究 解决了调控生物学中的基本问题，从而提供了 有机会制定适用于所有人的一般原则 哺乳动物。