ARTERIAL BAROREFLEX FUNCTION WITH AGING

动脉压力反射功能与衰老的关系

• 批准号: 2002144
• 负责人: Xiangrong Shi
• 金额: $ 6.13万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2002144
• 关键词: adult human (21+); aging; aorta; baroreceptors; baroreflex; blood pressure; blood volume; clinical research; heart rate; human subject; hypervolemia; hypovolemia; postural hypotension; vagus nerve

It is generally accepted that arterial baroreflex control and vagal control of heart rate is diminished with increases in age (>60 years) in the human. These phenomena have been used to explain the increased incidence of orthostatic hypotension observed in the healthy older population. More recently, however, we have documented that discrete carotid baroreflex control of the heart rate of healthy individuals 60-69 years of age was no different than that of healthy individuals 18-36 years of age. Therefore, we hypothesize, that the discrete aortic baroreceptor mediated reflex control of heart rate of the older individuals must be compromised. Other findings suggest that as individuals age the augmentation of the carotid-cardiac reflex control of heart rate by central hypovolemia, observed in young adults is diminished. Therefore, we further hypothesize that the interactions of carotid baroreflex function with the status of central blood volume (hypovolemia or hypervolemia) is diminished in older subjects (60-75 years). To test these hypotheses, we will isolate the carotid and aortic baroreflex control of heart rate during euvolemic, hypovolemic and hypervolemic central blood volumes, in a cross-sectional investigation of 18-36 year old adults and 60-75 year old adults of both genders. In addition, examination of the vagal control of heart rate using power spectral analysis will be made across all conditions and age groups. It is anticipated that the data obtained will provide us insight into the mechanism of altered arterial baroreflex control of heart rate of the elderly during orthostasis. Furthermore, we expect to develop a model of orthostatic hypotension upon which further investigations into the mechanisms of the age related increase in orthostatic hypotension can be made. Our long-term objectives are to understand the mechanisms of aging on human neurohumoral regulation of blood volume and blood pressure and to provide the basis for the use of prophylactic measures to enhance the quality of life of the elderly population.

一般认为，动脉压力反射控制与迷走神经有关

项目成果

Aging and arterial blood pressure variability during orthostatic challenge.

体位挑战期间的衰老和动脉血压变异性。

• DOI: 10.1159/000071708
• 发表时间: 2003
• 期刊: Gerontology
• 影响因子: 3.5
• 作者: Shi,Xiangrong;Huang,Guoyuan;Smith,ScottA;Zhang,Rong;Formes,KevinJ
• 通讯作者: Formes,KevinJ

Diminished forearm vasomotor response to central hypervolemic loading in aerobically fit individuals.

有氧运动个体对中心高容量负荷的前臂血管舒缩反应减弱。

• DOI: 10.1097/00005768-199611000-00007
• 发表时间: 1996
• 期刊: Medicine and science in sports and exercise
• 影响因子: 4.1
• 作者: Shi,X;Gallagher,KM;SMith,SA;Bryant,KH;Raven,PB
• 通讯作者: Raven,PB

Vagal cardiac function and arterial blood pressure stability.

迷走神经心脏功能和动脉血压稳定。

• DOI: 10.1152/ajpheart.2001.281.5.h1870
• 发表时间: 2001
• 期刊: American journal of physiology. Heart and circulatory physiology
• 作者: Wray,DW;Formes,KJ;Weiss,MS;O-Yurvati,AH;Raven,PB;Zhang,R;Shi,X
• 通讯作者: Shi,X