ARTERIAL BAROREFLEX FUNCTION WITH AGING
ARTERIAL BAROREFLEX FUNCTION WITH AGING
批准号:
2002144
负责人:
Xiangrong Shi
金额:
$6.13万
依托单位国家:
美国
项目类别:
财政年份:
1996
资助国家:
美国
项目状态:
已结题
起止时间:
1996-09-30 至 1998-08-31
中文摘要
一般认为,动脉压力反射控制和迷走神经
随着年龄的增长(>60岁),心率的控制能力减弱,
人类这些现象被用来解释
在健康老年人中观察到的体位性低血压的发生率
人口然而,最近,我们记录了离散的
颈动脉压力感受器反射对健康人心率的控制60-69
年龄与18-36岁的健康个体没有什么不同
岁的因此,我们假设,离散的主动脉
老年人压力感受器介导的心率反射控制
个人必须妥协。其他研究结果表明,作为
人的年龄增加的颈动脉心脏反射控制
在年轻人中观察到的中枢性低血容量引起的心率
减少了因此,我们进一步假设,
颈动脉压力感受性反射功能与中心血容量的关系
(低血容量或高血容量)在老年受试者(60-75
年)。为了验证这些假设,我们将分离颈动脉和主动脉
正常血容量、低血容量和低血容量期间心率的压力反射控制
高血容量中心血容量,在一项横断面调查中,
18-36岁的成年人和60-75岁的成年人。在
此外,使用功率检查迷走神经对心率的控制
将对所有条件和年龄组进行光谱分析。它
预计获得的数据将为我们提供深入了解
动脉压力感受性反射控制心率改变的机制
老年人在直立状态下。此外,我们希望开发一个模型,
直立性低血压,进一步研究
与年龄相关的直立性低血压增加的机制可能是
进行了我们的长期目标是了解衰老的机制
对人体血容量和血压的神经体液调节,
为使用预防措施提供依据,
老年人的生活质量。
英文摘要
It is generally accepted that arterial baroreflex control and vagal
control of heart rate is diminished with increases in age (>60 years) in
the human. These phenomena have been used to explain the increased
incidence of orthostatic hypotension observed in the healthy older
population. More recently, however, we have documented that discrete
carotid baroreflex control of the heart rate of healthy individuals 60-69
years of age was no different than that of healthy individuals 18-36
years of age. Therefore, we hypothesize, that the discrete aortic
baroreceptor mediated reflex control of heart rate of the older
individuals must be compromised. Other findings suggest that as
individuals age the augmentation of the carotid-cardiac reflex control of
heart rate by central hypovolemia, observed in young adults is
diminished. Therefore, we further hypothesize that the interactions of
carotid baroreflex function with the status of central blood volume
(hypovolemia or hypervolemia) is diminished in older subjects (60-75
years). To test these hypotheses, we will isolate the carotid and aortic
baroreflex control of heart rate during euvolemic, hypovolemic and
hypervolemic central blood volumes, in a cross-sectional investigation of
18-36 year old adults and 60-75 year old adults of both genders. In
addition, examination of the vagal control of heart rate using power
spectral analysis will be made across all conditions and age groups. It
is anticipated that the data obtained will provide us insight into the
mechanism of altered arterial baroreflex control of heart rate of the
elderly during orthostasis. Furthermore, we expect to develop a model of
orthostatic hypotension upon which further investigations into the
mechanisms of the age related increase in orthostatic hypotension can be
made. Our long-term objectives are to understand the mechanisms of aging
on human neurohumoral regulation of blood volume and blood pressure and
to provide the basis for the use of prophylactic measures to enhance the
quality of life of the elderly population.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
Aging and arterial blood pressure variability during orthostatic challenge.
体位挑战期间的衰老和动脉血压变异性。
DOI:
10.1159/000071708
发表时间:
2003
期刊:
Gerontology
影响因子:
3.5
作者:
[Shi,Xiangrong, Huang,Guoyuan, Smith,ScottA, Zhang,Rong, Formes,KevinJ]
通讯作者:
Formes,KevinJ
Diminished forearm vasomotor response to central hypervolemic loading in aerobically fit individuals.
有氧运动个体对中心高容量负荷的前臂血管舒缩反应减弱。
DOI:
10.1097/00005768-199611000-00007
发表时间:
1996
期刊:
Medicine and science in sports and exercise
影响因子:
4.1
作者:
[Shi,X, Gallagher,KM, SMith,SA, Bryant,KH, Raven,PB]
通讯作者:
Raven,PB
Vagal cardiac function and arterial blood pressure stability.
迷走神经心脏功能和动脉血压稳定。
DOI:
10.1152/ajpheart.2001.281.5.h1870
发表时间:
2001
期刊:
American journal of physiology. Heart and circulatory physiology
影响因子:
--
作者:
[Wray,DW, Formes,KJ, Weiss,MS, O-Yurvati,AH, Raven,PB, Zhang,R, Shi,X]
通讯作者:
Shi,X
Intermittent Hypoxia Training: A Novel Therapy for Mild Cognitive Impairment
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批准号:10615133
-
项目类别:
-
资助金额:$71.4万
-
财政年份:2022
-
负责人:Xiangrong Shi
-
依托单位:
Exercise Training and Vagal-Cardiac Function in Elderly
-
批准号:6781782
-
项目类别:
-
资助金额:$28.4万
-
财政年份:2002
-
负责人:Xiangrong Shi
-
依托单位:
Exercise Training and Vagal-Cardiac Function in Elderly
-
批准号:6470886
-
项目类别:
-
资助金额:$31.58万
-
财政年份:2002
-
负责人:Xiangrong Shi
-
依托单位:
Exercise Training and Vagal-Cardiac Function in Elderly
-
批准号:6607399
-
项目类别:
-
资助金额:$31.95万
-
财政年份:2002
-
负责人:Xiangrong Shi
-
依托单位:
Exercise Training and Vagal-Cardiac Function in Elderly
-
批准号:6899286
-
项目类别:
-
资助金额:$28.4万
-
财政年份:2002
-
负责人:Xiangrong Shi
-
依托单位:
海外基金