Exercise Training and Vagal-Cardiac Function in Elderly

老年人运动训练与迷走神经心脏功能

• 批准号: 6470886
• 负责人: Xiangrong Shi
• 金额: $ 31.58万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6470886
• 关键词: aerobic exercise; baroreflex; blood pressure; blood volume; clinical research; heart function; human old age (65+); human subject; human therapy evaluation; neurophysiology; physical fitness; postural hypotension; vagus nerve

DESCRIPTION (provided by applicant): It has been demonstrated in young adults that aerobic exercise training enhances cardiac parasympathetic (or vagal) nerve activity. This improved vagal-cardiac function is cardioprotective. Recently, we found that a compromised arterial blood pressure (ABP) regulation in elderly adults was associated with an age-related vagal dysfunction. Since aging is accompanied by chronic physical inactivity, questions remain as to whether aerobic exercise training can reverse the vagal dysfunction manifest in the elderly. We hypothesize that elderly adults with greater relative aerobic capacity will have greater autonomic neural control of the heart than their age matched counterparts and that the enhanced vagal-cardiac modulation resulting from exercise training will assist in APB stability at rest and during orthostatic challenge. We will test these hypotheses by evaluating vagally mediated control of cardiac function and baroreflex control of blood pressure in trained and in untrained elderly subjects aged 65 - 75 years. Selective muscarinic and beta1-adrenergic blockade will be used to determine the effects of endurance training on the specific neural area of the autonomic neural control of the heart affected by exercise training. Additionally, the effect of exercise training will be assessed by comparing untrained elderly subjects before and after one year of moderate intensity aerobic exercise training. Our long-term objectives are to understand the albeit regulatory mechanisms of blood pressure and blood volume due to age and to provide the basis for the use of prophylactic measure to improve the quality of human life.

描述（由申请人提供）：已在年轻成人中得到证实 有氧运动训练增强心脏副交感神经（或迷走神经） 神经活动这种改善的迷走神经-心脏功能具有心脏保护作用。 最近，我们发现动脉血压（ABP）调节受损， 与年龄相关的迷走神经功能障碍有关。以来 衰老伴随着慢性身体活动不足，问题仍然存在， 有氧运动训练是否可以逆转迷走神经功能障碍， 老人我们假设，老年人与更大的相对有氧 能力将有更大的自主神经控制的心脏比他们的年龄 匹配的对应物，并且增强的迷走神经-心脏调制导致 将有助于APB在休息时和 立位挑战我们将通过评估迷走神经来检验这些假设。 心脏功能的介导控制和血压的压力反射控制 在年龄为65 - 75岁的受过训练和未经训练的老年受试者中。选择性 将使用毒蕈碱和β 1-肾上腺素能阻滞剂来确定效应 耐力训练对自主神经的特定神经区域 心脏控制受运动训练的影响。此外，影响 运动训练将通过比较未经训练的老年受试者 在一年的中等强度有氧运动训练之前和之后。我们 长期目标是了解尽管监管机制， 血压和血容量因年龄而异，并为使用提供依据 预防措施，以提高人类生活质量。