Exercise Training and Vagal-Cardiac Function in Elderly

老年人运动训练与迷走神经心脏功能

• 批准号: 6781782
• 负责人: Xiangrong Shi
• 金额: $ 28.4万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6781782
• 关键词: aerobic exercise; baroreflex; blood pressure; blood volume; clinical research; heart function; human old age (65+); human subject; human therapy evaluation; neurophysiology; physical fitness; postural hypotension; vagus nerve

DESCRIPTION (provided by applicant): It has been demonstrated in young adults that aerobic exercise training enhances cardiac parasympathetic (or vagal) nerve activity. This improved vagal-cardiac function is cardioprotective. Recently, we found that a compromised arterial blood pressure (ABP) regulation in elderly adults was associated with an age-related vagal dysfunction. Since aging is accompanied by chronic physical inactivity, questions remain as to whether aerobic exercise training can reverse the vagal dysfunction manifest in the elderly. We hypothesize that elderly adults with greater relative aerobic capacity will have greater autonomic neural control of the heart than their age matched counterparts and that the enhanced vagal-cardiac modulation resulting from exercise training will assist in APB stability at rest and during orthostatic challenge. We will test these hypotheses by evaluating vagally mediated control of cardiac function and baroreflex control of blood pressure in trained and in untrained elderly subjects aged 65 - 75 years. Selective muscarinic and beta1-adrenergic blockade will be used to determine the effects of endurance training on the specific neural area of the autonomic neural control of the heart affected by exercise training. Additionally, the effect of exercise training will be assessed by comparing untrained elderly subjects before and after one year of moderate intensity aerobic exercise training. Our long-term objectives are to understand the albeit regulatory mechanisms of blood pressure and blood volume due to age and to provide the basis for the use of prophylactic measure to improve the quality of human life.

描述（由申请人提供）：已在年轻人中证明 有氧运动训练增强了心脏副交感神经（或迷走神经） 神经活动。这种改善的迷走神经功能是心脏保护。 最近，我们发现动脉血压（ABP）调节受损 在老年人中，成年人与年龄相关的迷走神经功能障碍有关。自从 衰老伴随着长期的身体不活动，有关 有氧运动训练是否可以扭转迷走神经功能障碍。 老人。我们假设具有较高相对有氧运动的老年人 能力将比其年龄更大的心脏自主神经控制 匹配的对应物，并增强了迷走神经调节 从锻炼训练将有助于静止和期间的APB稳定性 体位挑战。我们将通过模糊评估来检验这些假设 对心脏功能的介导控制和血压的压力反射控制 在65-75岁的未经训练和未经训练的老年受试者中。选择性 毒蕈碱和β1-肾上腺素能阻断将用于确定影响 关于自主神经特定神经区域的耐力训练 控制心脏受运动训练影响的心脏。另外， 将通过比较未经训练的老年人来评估运动训练 一年中期的有氧运动训练前后。我们的 长期目的是了解尽管有监管机制 血压和血液体积由于年龄而提供的基础 预防性措施以改善人类生活的质量。