Regulation of 3D Cell Migration by Microtubule-Dependent Processes

通过微管依赖性过程调节 3D 细胞迁移

• 批准号: FT190100516
• 负责人: Dr Sam Stehbens
• 金额: $ 52.51万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT190100516
• 关键词: Regulation; 3D; Cell; Migration; Microtubule

The overarching aim of this research is to elucidate the molecular mechanisms that cells use to move in 3D environments: a basic biological function essential to development and homeostasis. During these processes, cells interact with their surroundings where they translate biophysical forces into biochemical signals to adapt their shape to move. This requires distinct signalling, controlled in space and time, to regulate the crosstalk between organelles and the cytoskeleton. To date, the role of microtubules remains elusive. Using interdisciplinary approaches combining advanced imaging technology with novel cell biology methods, the project aims to uncover fundamental knowledge about how cells interact with their environment.

本研究的总体目标是阐明细胞在三维环境中移动的分子机制：一种对发育和体内平衡至关重要的基本生物学功能。在这些过程中，细胞与周围环境相互作用，将生物物理力转化为生化信号，以适应它们的形状来移动。这需要不同的信号，在空间和时间上控制，以调节细胞器和细胞骨架之间的串扰。迄今为止，微管的作用仍然难以捉摸。该项目采用跨学科的方法，将先进的成像技术与新颖的细胞生物学方法相结合，旨在揭示细胞如何与环境相互作用的基本知识。