METALLO-SULFUR COMPLEXES AS MODELS FOR ELECTRON TRANSFER PROTEINS

金属硫络合物作为电子转移蛋白的模型

• 批准号: 3755828
• 负责人: DONALD R PAULSON
• 金额: --
• 依托单位: CALIFORNIA STATE UNIVERSITY LOS ANGELES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3755828
• 关键词: chemical models; deuterium; dithiol; electron transport; hemoprotein; iron sulfur protein; metal complex; oxidation; transport proteins

The chemistry of metal-dithiolate complexes and metal disulfide complexes will be studied as model systems for metallo-thiolate electron transport proteins such as the ubiquitous iron-sulfur proteins. It is proposed that these metalloproteins can obtain additional reducing power by the formation partial S.S bonds through interaction of two adjacent metal-bound thiolates. Evidence for this hypothesis comes from a number of examples of metal-thiolate complexes where the S.S separations are considerably smaller than the predicted nearest neighbor contact of non-bonded sulfur atoms. Metallosulfur complexes will be synthesized where the dithiolate/disulfide couple is reversible. Dithiolate complexes will be prepared with high-valent metal ions while disulfide complexes will be prepared with low-valent metal ions. The oxidation of the thiolate complexes and the reduction of the disulfide complexes will be studied in order to provide further evidence for the dithiolate/disulfide couple serving as a source of increased reducing power in electron transfer proteins.

金属-二硫酯配合物和金属二硫化物的化学性质