FOLLICULAR DENDRITIC CELLS AND IMMUNOSUPPRESSION IN AIDS
艾滋病中的滤泡树突细胞和免疫抑制
基本信息
- 批准号:2067275
- 负责人:
- 金额:$ 9.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1993
- 资助国家:美国
- 起止时间:1993-07-01 至 1998-06-30
- 项目状态:已结题
- 来源:
- 关键词:AIDS B lymphocyte antiviral antibody complement complement pathway dendritic cells flow cytometry helper T lymphocyte human immunodeficiency virus human tissue immunosuppression laboratory mouse mixed lymphocyte reaction test passive immunization polymerase chain reaction tissue /cell culture virus infection mechanism virus replication
项目摘要
Follicular dendritic cells (FDC) play a major role in immunoregulation
and have recently been found to be a site of HIV deposition. FDC serve
as long-term depots of Ag for induction and maintenance of anamnestic
responses as well as contributing Ag independent signalling believed to
be necessary for germinal center formation. In order for Ag (or
infectious agents) to become associated with FDC, either specific Ab
and/or complement activation is required. After one or both of these
events have occurred, immune complexes or complement coated particles are
formed and can be trapped on the dendritic surfaces of FDC. Shortly
after trapping on FDC, germinal center formation occurs. These germinal
centers are composed of highly activated and rapidly proliferating B (and
CD4+ T) cells surrounding FDC. In HIV infection, viral particles quickly
become associated with FDC in lymphoid follicles although the mechanism
of this association has not been established. Once trapped on FDC, virus
is localized to the germinal center area where susceptible cells reside
in a highly activated state. Thus HIV localization on FDC apparently
brings together all of the components needed for successful and
productive infection of CD4 + T cells and keeps them together as long as
the FDC are present. We hypothesize that FDC by virtue of trapped HIV
and generation of costimulatory signals play a vital role In the
pathogenesis of AIDS and propose to test this using both in vivo and in
vitro models. The specific aims of this proposal are to: 1) determine if
HIV can specifically target itself to FDC and if this targeting is
accomplished by complement activation, specific Ab or a combination of
both; 2) determine whether FDC bearing HIV can directly infect activated
CD4 + T cells and to assess the contribution of HIV specific Ab on this
infectious process; and 3) determine whether FDC and/or germinal center B
cells can provide sufficient accessory cell function to promote
productive infection of resting CD4 + T cells.
滤泡树突状细胞(FDC)在免疫调节中发挥重要作用
最近被发现是艾滋病毒沉积的场所。 FDC服务
作为银的长期储存库,用于诱导和维持记忆
反应以及贡献Ag独立信号被认为是
是生发中心形成所必需的。 为了Ag(或
传染性病原体)与 FDC 相关,无论是特定抗体
和/或需要补体激活。 经过其中一项或两项之后
事件发生后,免疫复合物或补体包被的颗粒
形成并可以被捕获在 FDC 的树枝状表面上。 不久
在 FDC 捕获后,发生生发中心形成。 这些生发
中心由高度激活和快速增殖的B(和
FDC 周围的 CD4+ T) 细胞。 在艾滋病毒感染中,病毒颗粒很快
与淋巴滤泡中的 FDC 相关,但其机制
该协会尚未成立。 一旦被困在FDC上,病毒
位于易感细胞所在的生发中心区域
处于高度活跃状态。 因此,FDC 上的 HIV 定位显然
汇集了成功所需的所有组件
CD4 + T 细胞的有效感染并使它们保持在一起
FDC 也在场。 我们假设 FDC 凭借捕获的 HIV
和共刺激信号的产生在
艾滋病的发病机制,并建议使用体内和体内测试来测试这一点
体外模型。 该提案的具体目标是: 1) 确定是否
HIV 可以专门针对 FDC 进行自身靶向,并且如果该靶向是
通过补体激活、特异性抗体或以下物质的组合来完成
两个都; 2) 确定携带HIV的FDC是否可以直接感染激活的
CD4 + T 细胞并评估 HIV 特异性抗体对此的贡献
感染过程; 3)确定FDC和/或生发中心B是否
细胞可以提供足够的辅助细胞功能以促进
静息 CD4 + T 细胞的生产性感染。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gregory F. Burton其他文献
Gregory F. Burton的其他文献
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{{ truncateString('Gregory F. Burton', 18)}}的其他基金
Follicular dendritic cell activation and HIV pathogenesis
滤泡树突状细胞激活和 HIV 发病机制
- 批准号:
8012521 - 财政年份:2010
- 资助金额:
$ 9.99万 - 项目类别:
FOLLICULAR DENDRITIC CELLS AND HIV PATHOGENESIS
滤泡树突细胞和 HIV 发病机制
- 批准号:
2442700 - 财政年份:1996
- 资助金额:
$ 9.99万 - 项目类别:
FOLLICULAR DENDRITIC CELLS AND HIV PATHOGENESIS
滤泡树突细胞和 HIV 发病机制
- 批准号:
2076912 - 财政年份:1996
- 资助金额:
$ 9.99万 - 项目类别:
FOLLICULAR DENDRITIC CELLS AND HIV PATHOGENESIS
滤泡树突细胞和 HIV 发病机制
- 批准号:
2887219 - 财政年份:1996
- 资助金额:
$ 9.99万 - 项目类别:
Follicular Dendritic Cells and HIV Pathogenesis
滤泡树突状细胞和 HIV 发病机制
- 批准号:
7073866 - 财政年份:1996
- 资助金额:
$ 9.99万 - 项目类别:
FOLLICULAR DENDRITIC CELLS AND HIV PATHOGENESIS
滤泡树突细胞和 HIV 发病机制
- 批准号:
2672780 - 财政年份:1996
- 资助金额:
$ 9.99万 - 项目类别:
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