Metabolic control of gene expression networks and microbiome interactions

基因表达网络和微生物组相互作用的代谢控制

• 批准号: FT190100733
• 负责人: Prof Ana Traven
• 金额: $ 72.08万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT190100733
• 关键词: Metabolic; control; gene; expression; networks

The proposal aims to advance our understanding of how metabolism (and resulting metabolites) regulate the expression of genes, and investigate how these processes dictate the interaction of microbiota with the immune system. The project is expected to generate transformative knowledge of gene regulation, a fundamental process for cellular function, and decipher how the microbiome yeast Candida albicans interacts with immune cells and bacteria. By utilising a powerful combination of molecular and systems biology with molecular genetics and imaging, the project outcomes should foster interdisciplinary collaborations and build capacity for fundamental and applied research to benefit academia and industry, locally and globally.

该提案旨在促进我们对代谢（以及由此产生的代谢物）如何调节基因表达的理解，并研究这些过程如何决定微生物群与免疫系统的相互作用。该项目有望产生基因调控的革命性知识，这是细胞功能的基本过程，并破译微生物组酵母菌白色念珠菌如何与免疫细胞和细菌相互作用。通过利用分子和系统生物学与分子遗传学和成像的强大结合，项目成果应该促进跨学科合作，并建立基础和应用研究的能力，使本地和全球的学术界和工业界受益。