EPIDEMIOLOGY OF HUMAN RETROVIRUSES IN BLOOD DONORS

献血者中人类逆转录病毒的流行病学

• 批准号: 2313343
• 负责人: STEVEN KLEINMAN
• 金额: $ 87.48万
• 依托单位: AMERICAN NATIONAL RED CROSS LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-17 至 1998-08-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2313343
• 关键词: EPIDEMIOLOGY; HUMAN; RETROVIRUSES; BLOOD; DONORS

The objective of this contract are as follows: 1) determine the prevalence of retrovirus seropositivity in first time blood donors; 2) determine the rate of retrovirus seroconversion in repeat blood donors as a measure of incidence of infection; 3) ascertain risk factors for antibody-positive donors; 4) characterize the blood donor population by geographic location, age, sex, race/ethnicity, and donation history to permit analysis on prevalence, incidence, and risk factors; 5) identify recipients of retrovirus-positive blood units and conduct clinical and laboratory follow-up of these recipients to determine the transmissibility of these agents via transfusion; and 6) establish blood specimen repositories for long-term storage of specimens from study donors and recipients for future testing.

本合同的目的如下：1）确定 首次献血者逆转录病毒血清阳性率; 2） 确定重复献血者的逆转录病毒血清转化率， 感染发生率的测量; 3）确定 抗体阳性供体; 4）通过以下方式表征献血者群体： 地理位置、年龄、性别、种族/民族和献血史， 允许分析患病率、发生率和风险因素; 5）识别 接受逆转录病毒阳性血液单位，并进行临床和 对这些接受者进行实验室随访， 这些药剂通过输血的传播性;以及6）建立血液 用于长期储存研究标本的标本库 供者和受者进行进一步的测试。