MOLECULAR EPIDEMIOLOGY OF HUMAN RETROVIRUSES: HIV IN ASIA & PACIFIC

人类逆转录病毒的分子流行病学：亚洲的艾滋病毒

• 批准号: 6121545
• 负责人: Cecilia M. Shikuma
• 金额: $ 33.9万
• 依托单位: UNIVERSITY OF HAWAII AT MANOA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-14 至 1999-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6121545
• 关键词: AIDS; Asians; communicable diseases; epidemiology; immunology; inflammation; lymphatic system; virus

For most of Asia and the Pacific, the acquired immunodeficiency syndrome (AIDS) had not been identified prior to the late l 980s and the number of cumulative cases is still quite low (I). However, AIDS is now a public health emergency in Thailand, and many neighboring countries are also at high risk of epidemic spread of human immunodeficiency virus type (HIV-l) infection.For example, studies in Papua New Guinea (the largest and most populous of the Pacific island nations) indicate widespread high-risk sexual behaviors and high rates of sexually transmitted diseases, particularly ulcerative genital conditions. Vital baseline data are needed on the HIV-1 subtypes present in Southeast Asia and in countries, like Papua New Guinea, where health care delivery systems and high rates of syphilis and tuberculosis are comparable to those in sub-Saharan Africa. Also, the endemicity of human T-cell lymphotropic virus type I (HTLV-I) infection in some Melanesian populations in Papua New Guinea places such groups at added risk for HIV-1 infection because of the immunosuppressive and T-cell activation properties of HTLV-I.

对于大多数亚洲和太平洋地区来说，获得性免疫缺陷 综合症(艾滋病)在L 980年代末之前没有被发现， 累计病例数量仍然相当低(I)。然而，艾滋病 现已成为泰国的公共卫生紧急状态，以及许多邻国 各国也处于人类流行病传播的高风险之中。 免疫缺陷病毒(艾滋病毒-L)感染。例如，在 巴布亚新几内亚(太平洋上面积最大、人口最多的岛屿 国家)表明普遍的高危性行为和高比率 性传播疾病，特别是溃烂生殖器 条件。需要关于艾滋病毒-1亚型的重要基线数据 在东南亚和巴布亚新几内亚等国家都有业务， 在那里，医疗保健提供系统和高梅毒感染率以及 结核病可与撒哈拉以南非洲的结核病相媲美。另外， 人T细胞嗜淋病病毒I型的地方性研究 巴布亚新几内亚一些美拉尼西亚人的感染情况 这类人群感染HIV-1的风险增加，因为 HTLV-I的免疫抑制和T细胞活化特性