IMPROVED BIOCOMPATIBILITY OF PERITONEAL DIALYSIS TUBING

提高腹膜透析管的生物相容性

• 批准号: 3638585
• 负责人: SHAWN G DUNKIRK
• 金额: $ 22.92万
• 依托单位: SURMODICS, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-22 至 1991-09-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3638585
• 关键词: biomaterial development /preparation; biomaterial interface interaction; clinical biomedical equipment; dialysis therapy; laboratory rat; peptides

The Contractor will continue to optimize chemistries for improvements of additional dialysis materials. The Contractor will enlarge his repertoire of surface-modification reagents to include those with anticoagulant and antimicrobial activities, surface-modify various types of dialysis fibers with these new derivatives, the test the patency and equilibration times required for efficient collection of model peptides in an in vitro system. Following this, dialysis fibers will be implanted in an animal model (the rat) and the delivery and collection of model peptides (basis, acidic, and hydrophobic) will be measured over a period of weeks.

承包商将继续优化化学品， 其他透析材料。 承包商将扩大他的剧目 表面改性试剂，包括那些与抗凝剂和 抗菌活性，表面改性各种类型的透析纤维 使用这些新衍生物，测试通畅性和平衡时间 这是在体外系统中有效收集模型肽所需的。 在此之后，透析纤维将被植入动物模型中（ 大鼠）和模型肽（碱性、酸性和 疏水性）将在数周的时间内测量。