IMPROVED BIOCOMPATIBILITY OF INTRAOCULAR LENSES

改善人工晶状体的生物相容性

• 批准号: 3507638
• 负责人: SHAWN G DUNKIRK
• 金额: $ 25.67万
• 依托单位: SURMODICS, INC.
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-30 至 1990-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3507638
• 关键词: binding proteins; biological models; biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; biomaterials; cataract surgery; collagen; corneal endothelium; covalent bond; eye prosthesis; fibronectins; growth factor; guinea pigs; hyaluronate; laboratory mouse; laboratory rabbit; photochemistry; photolysis; polymers; scanning electron microscopy; surface property; tissue /cell culture; toxicant screening; viscosity

Intraocular lens implants (IOL's) have returned vision to cataract patients. The implant provides visual acuity which is not distorted or magnified as is vision resulting from wearing thick- lensed spectacles or contact lenses. However, as with all other implant able devices, there are problems with the biocompatibility of the synthetic materials with the tissues of the eye. Inadvertant contact between the lens and the cornea or other eye tissues at the time of implant or while the IOL is being carried by the patient, can cause serious and irreparable damage and result in removal of lenses. During Phase I we covalently attached polymers to IOL haptics and optics, demonstrated improved surface characteristics of the modified IOL's in a cadaver eye model an demonstrated preliminary in vivo indications of the acceptance of the modified IOL's in a feline model. During this Phase II project, we will optimize and develop the synthesis and application of the coating polymers, extensively demonstrate the lack of toxicity of these materials; indicate the usefulness of these coatings by in vitro tissue culture analyses, and up to one year animal implant studies. The favorable results of this project will lead to implants in primates and ultimately clinical testing. Such lens modification is expected to decrease the complications associated with IOL wear and make the implantation of an artificial lens feasible for even greater numbers of patients for a lifetime of improved vision.

人工晶状体植入术（IOL）使白内障患者的视力恢复正常 患者。 植入物提供的视力不是 因穿着厚衣服而导致视力扭曲或放大 镜片眼镜或隐形眼镜。 然而，与所有其他 植入式设备存在问题 合成材料与组织的生物相容性 眼睛。 镜片和角膜之间的无意接触或 植入时或人工晶状体植入时的其他眼组织 由患者携带，可能造成严重且不可挽回的损害 并导致镜片摘除。 在第一阶段，我们共价 将聚合物附着到 IOL 触觉和光学器件上，已证明 改进的人工晶状体的表面特性 尸体眼模型在体内进行了初步论证 猫科动物接受改良人工晶状体的迹象 模型。 在这个二期项目中，我们将优化和 开发涂料聚合物的合成和应用， 广泛证明这些材料没有毒性； 通过体外组织表明这些涂层的有用性 培养分析以及长达一年的动物植入研究。 这 该项目的良好结果将导致在灵长类动物中进行植入 并最终进行临床测试。 这样的镜头修改是 有望减少 IOL 相关并发症 佩戴并使得人工晶状体的植入成为可能 甚至更多的患者终生获得改善 想象。