SURFACE MODIFICATION OF CORNEAL OVERLAY IMPLANTS

角膜覆盖植入物的表面修饰

• 批准号: 3497041
• 负责人: SHAWN G DUNKIRK
• 金额: $ 4.98万
• 依托单位: SURMODICS, INC.
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-07-15 至 1990-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3497041
• 关键词: astigmatism; basement membrane; cell adhesion; cell growth regulation; cornea; covalent bond; epithelium; gel filtration chromatography; growth factor; lens; membrane proteins; radiotracer; refractive keratoplasty; scintillation counter; surface property; tissue /cell culture

The long-term objective of this project is to improve the surface- properties of artificial cornea overlay implants for use in refractive surgical procedures. This will be done by covalently immobilizing cell adhesion proteins to these lenses to promote epithelialization over the synthetic materials. The specific aims of this Phase I project will be to use proprietary chemistries to prepare derivatives of cell adhesion proteins demonstrate covalent immobilization of these factors to lens materials, and show that such surface modifications will promote more rapid and adherent outgrowth of corneal epithelium over the lenses. Stable and rapid overgrowth and adhesion of corneal epithelial cells will be a necessity for the successful replacement of cornea with synthetic materials. The potential for this research is to make possible the use of corneal overlay procedures for correction of aphakia, myopia, and astigmatism. This procedure could be made elective for the millions of patients (135 million in the U.S., alone, 1986) who may desire improved vision without the use and bother of contact lenses of spectacles.

该项目的长期目标是改善表面- 用于屈光手术的人工角膜覆盖植入物的性能 外科手术 这将通过共价固定细胞来完成 粘附蛋白，以促进上皮形成， 合成材料。 第一阶段项目的具体目标是 使用专有的化学物质来制备细胞粘附的衍生物， 蛋白质证明这些因子共价固定到透镜上 材料，并表明这种表面改性将促进更多 角膜上皮在晶状体上快速粘附生长。 角膜上皮细胞的稳定和快速过度生长和粘附将 是成功地用人造角膜替换角膜的必要条件， 材料. 这项研究的潜力是使使用 用于矫正无晶状体眼、近视和 散光这一程序可以成为数百万人的选择性程序， 患者（美国1.35亿，1986年，他希望自己能有所改善。 不使用隐形眼镜或眼镜的视力。