Determination of the link between hypertension and Covid-19

确定高血压与 Covid-19 之间的联系

• 批准号: 62125
• 金额: $ 6.04万
• 依托单位: CLOSED LOOP MEDICINE LTD
• 依托单位国家: 英国
• 项目类别: Feasibility Studies
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=62125
• 关键词: Determination; link; between; hypertension; Covid

Hypertension (uncontrolled high blood pressure) is the leading preventable cause of premature death worldwide. Globally, 1.39bn people are estimated to have hypertension, and it caused ~10.7 million deaths in 2015\. It is projected to affect more than 1.5 billion people around the world by 2025\.In the UK ~30% of adults have hypertension, 9.5m have a diagnosis, and a further 5m people in England alone may have hypertension yet be unaware.In the current pandemic of COVID-19, people with hypertension are facing additional challenges in managing their condition as they are:\*socially isolating and not being able to meet with their GP/Healthcare Professional (HCP) with the same frequency\*reading stories in the press and scientific literature that indicate that a high percentage of patients with hypertension who contract COVID-19 have severe illness, are admitted to an intensive care unit, receive mechanical ventilation, or die.Being able to remotely monitor people with hypertension through use of a phone app that records daily BP readings, current treatment regimens and indicate any COVID-19 symptoms will address a current clinical need and enable medical management and patient engagement without the need for direct patient-HCP contact.We aim to update an already developed phone app designed for a hypertension focussed clinical study to include additional features for deployment in a new clinical trial in a COVID-19 setting. The trial will aim to demonstrate a "business as usual" approach to managing and monitoring a long term condition as well as collecting data help to answer questions that are of concern for the hypertension community namely:\*Does blood pressure drug use and/or level of blood pressure control affect risk of COVID-19 infection?\*Does blood pressure drug use and/or level of blood pressure control affect severity of COVID-19 illness/pneumonia?\*Do particular types of blood pressure medication affect risk of COVID-19 infection?

高血压（不受控制的高血压）是全世界过早死亡的主要可预防原因。全球估计有 13.9 亿人患有高血压，2015 年约 1070 万人因此死亡。预计到 2025 年，它将影响全球超过 15 亿人\。在英国，约 30% 的成年人患有高血压，950 万人被诊断出患有高血压，仅在英格兰就有 500 万人可能患有高血压但尚未意识到。在当前的 COVID-19 大流行中，高血压患者在管理自己的病情方面面临着额外的挑战，因为他们：\*社会孤立且无法与家人见面 全科医生/医疗保健专业人员 (HCP) 以相同的频率\*阅读新闻和科学文献中的故事，这些故事表明感染 COVID-19 的高血压患者有很高比例患有严重疾病、被送进重症监护室、接受机械通气或死亡。能够通过使用记录每日血压读数、当前治疗方案并指示任何 COVID-19 症状的手机应用程序来远程监测高血压患者 满足当前的临床需求，并实现医疗管理和患者参与，而无需患者与 HCP 直接接触。我们的目标是更新专为高血压临床研究而设计的已开发的手机应用程序，以包括在 COVID-19 环境下的新临床试验中部署的附加功能。该试验旨在展示“一切照旧”的方法来管理和监测长期病情，并收集有助于回答高血压社区关心的问题的数据，即：\*降压药物的使用和/或血压控制水平是否会影响 COVID-19 感染的风险？\*降压药物的使用和/或血压控制水平是否会影响 COVID-19 疾病/肺炎的严重程度？\*特定类型的血压会影响血压吗？ 药物会影响感染 COVID-19 的风险吗？