BIOMPHALARIA OBSTRUCTA/SCHISTOSOMA MANSONI INTERACTIONS

对感染不敏感的机制 尚不清楚光滑双脐螺中的曼氏血吸虫。 其中提出的假设是生理上的不适应， 免疫抵抗，后者涉及快速，血细胞介导的 初级孢子囊的破坏后，识别的 寄生虫作为非我（例如，通过血浆或细胞表面凝集素）和/或 无法将寄生虫识别为自身。 在B。obulta，a North 美洲种完全难治的感染与S。曼索尼大部分 孢子囊不会被血细胞反应破坏， 退化，并且孢子囊存活在感染了 棘口吸虫 这项建议旨在（1）确定 色葡萄棘口吸虫感染的B.（2）确定 S的命运曼氏菌在自然感染白蛉螺体内的表达 或一个strigeid;（3）确定是否增强抵抗发生对 E.（4）探讨了对S. mansoni

Mechanisms responsible for nonsusceptibility to infection with Schistosoma mansoni in Biomphalaria glabrata snails are not known. Among the hypotheses proposed are physiological unsuitability and immunological resistance, the latter involving rapid, hemocyte-mediated destruction of the primary sporocyst following recognition of the parasite as nonself (e,g., by plasma or cell surface lectins) and/or failure to recognize the parasite as self. In B. obstructa, a North American species totally refractory to infection with S. mansoni, most sporocysts are not destroyed by a hemocytic response, but instead degenerate, and sporocyst survival is increased in snails infected with Echinostoma paraensei. This proposal seeks to (1) ascertain the fate of S. mansoni in echinostome-infected B. obstructa; (2) ascertain the fate of S. mansoni in snails naturally-infected with Ribeiroia ondatrae or a strigeid; (3) determine whether enhanced resistance occurs against E. paraensei; and (4) study the mechanism of nonsusceptibility to S. mansoni.