BIOMPHALARIA OBSTRUCTA/SCHISTOSOMA MANSONI INTERACTIONS

感染不易感性的机制 曼氏血吸虫在光滑生物钉螺中的分布尚不清楚。 提出的假设包括生理上的不适宜性和 免疫抵抗，后者涉及快速的、血细胞介导的 在认识到原发孢子囊的情况下 作为非我的寄生虫(例如，通过血浆或细胞表面凝集素)和/或 没能认出寄生虫是自己。在B·阻挠，一个北方 美国物种对曼氏葡萄球菌感染完全耐药，大多数 孢子囊不是通过血细胞反应来摧毁的，而是相反的 感染的钉螺退化，孢子囊存活率增加 巴氏棘口吸虫。这项建议旨在(1)确定命运 在棘口吸虫感染的阻塞性巴氏杆菌中发现曼氏血吸虫； 自然感染Ribeiroia ondatrae的钉螺体内曼氏血吸虫的命运 或粗线体；(3)确定是否对 研究了沙门氏菌对沙门氏菌不敏感的机制。 曼索尼。

Mechanisms responsible for nonsusceptibility to infection with Schistosoma mansoni in Biomphalaria glabrata snails are not known. Among the hypotheses proposed are physiological unsuitability and immunological resistance, the latter involving rapid, hemocyte-mediated destruction of the primary sporocyst following recognition of the parasite as nonself (e,g., by plasma or cell surface lectins) and/or failure to recognize the parasite as self. In B. obstructa, a North American species totally refractory to infection with S. mansoni, most sporocysts are not destroyed by a hemocytic response, but instead degenerate, and sporocyst survival is increased in snails infected with Echinostoma paraensei. This proposal seeks to (1) ascertain the fate of S. mansoni in echinostome-infected B. obstructa; (2) ascertain the fate of S. mansoni in snails naturally-infected with Ribeiroia ondatrae or a strigeid; (3) determine whether enhanced resistance occurs against E. paraensei; and (4) study the mechanism of nonsusceptibility to S. mansoni.