BIOMPHALARIA OBSTRUCTA/SCHISTOSOMA MANSONI INTERACTIONS

阻塞性生物疟原虫/曼索尼血吸虫的相互作用

• 批准号: 6401585
• 负责人: JOHN T. SULLIVAN
• 金额: $ 3.86万
• 依托单位: UNIVERSITY OF SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6401585
• 关键词: Biomphalaria; Schistosoma mansoni; immunology; parasitism

Mechanisms responsible for nonsusceptibility to infection with Schistosoma mansoni in Biomphalaria glabrata snails are not known. Among the hypotheses proposed are physiological unsuitability and immunological resistance, the latter involving rapid, hemocyte-mediated destruction of the primary sporocyst following recognition of the parasite as nonself (e,g., by plasma or cell surface lectins) and/or failure to recognize the parasite as self. In B. obstructa, a North American species totally refractory to infection with S. mansoni, most sporocysts are not destroyed by a hemocytic response, but instead degenerate, and sporocyst survival is increased in snails infected with Echinostoma paraensei. This proposal seeks to (1) ascertain the fate of S. mansoni in echinostome-infected B. obstructa; (2) ascertain the fate of S. mansoni in snails naturally-infected with Ribeiroia ondatrae or a strigeid; (3) determine whether enhanced resistance occurs against E. paraensei; and (4) study the mechanism of nonsusceptibility to S. mansoni.

不敏感感染的机制 光滑双脐螺中的曼氏血吸虫尚不清楚。 提出的假设包括生理上的不适宜性和 免疫抵抗，后者涉及快速的、血细胞介导的 识别后初级孢子被破坏 寄生虫作为非自身（例如，通过血浆或细胞表面凝集素）和/或 无法将寄生虫识别为自身。 在 B.obstructa 中，北 美洲物种对曼氏沙门氏菌感染完全抵抗，大多数 孢子被不会被血细胞反应破坏，而是被破坏 退化，并且感染的蜗牛的孢子被存活率增加 帕拉恩塞棘口虫。 该提案旨在 (1) 确定命运 感染棘口虫的 B.obstructa 中的曼氏沙门氏菌； (2) 确定 曼氏沙门氏菌在自然感染 Ribeiroia ondatrae 的蜗牛中的命运 或斯特里格德； (3) 判断抗性是否增强 帕拉恩氏菌； (4)研究对S.的不敏感机制。 曼索尼.

项目成果

Hematopoietic tissue allografts in Biomphalaria glabrata (Mollusca: Pulmonata) induce humoral immunity to Schistosoma mansoni.

光滑双脐动物（软体动物：肺动物）的造血组织同种异体移植物可诱导对曼氏血吸虫的体液免疫。

• DOI: 10.1016/s0145-305x(01)00022-2
• 发表时间: 2001
• 期刊: Developmental and comparative immunology
• 影响因子: 2.9
• 作者: Vasquez,RE;Sullivan,JT
• 通讯作者: Sullivan,JT