权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Plasma resistance factors in Biomphalaria glabrata

光滑双脐螺的血浆抗性因子

基本信息

批准号：
6412484
负责人：
JOHN T. SULLIVAN
金额：
$ 13.75万
依托单位：
UNIVERSITY OF SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-05-01 至 2006-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6412484
关键词：
Biomphalaria Schistosoma mansoni autoimmunity blood fractionation blood proteins cell mediated cytotoxicity emerging infectious disease erythrocytes gel electrophoresis immunity interleukin 1 parasite infection mechanism parasitism plasma schistosomiasis superoxides western blottings

项目摘要

DESCRIPTION: Mechanisms responsible for no susceptibility to infection with Schistosoma mansoni in Biomphalaria glabrata snails are not well understood. The most likely explanation for non-susceptibility is immunological resistance, possibly involving (1) recognizing the parasite as non-self and/or failing to recognize the parasite as self, (2) mounting a cytotoxic response against the sporocyst, as well as (3) withstanding or countering parasite immunosuppressive factors, which could interfere with (1) or (2). Both cellular and humoral mechanisms (which may act independently or in concert with hemocytes) have been implicated in sporocyst destruction. This resistance can be transferred to non-susceptible snails both adoptively, by transplants of the hematopoietic amebocyte-producing organ (APO) or passively, by injections of plasma. Although passive transfer was described over 16 years ago, it has remained uninvestigated, despite the potential for elucidating humoral mechanisms of schistosome resistance. Preliminary studies have confirmed the presence of resistance factor in plasma from additional types of resistant snails, and have provided new information on the duration of the effect, the fate of sporocysts in snails with passively transferred resistance, as well as the resistance factor molecular weight and source. This proposal seeks to further characterize passively transferred resistance to S. mansoni and to identify the relevant plasma resistance factor(s).

描述：对感染不敏感的机制光滑双脐螺中的曼氏血吸虫尚不清楚。不敏感的最可能的解释是免疫抵抗，可能涉及（1）认识到寄生虫是非自我和/或未能将寄生虫识别为自身，（2）针对寄生虫产生细胞毒性反应孢子被，以及（3）抵抗或抵抗寄生虫免疫抑制可能干扰（1）或（2）的因素。细胞和体液两方面机制（可以独立作用或与血细胞协同作用）与孢子被破坏有关。这个阻力可以转移到不敏感的蜗牛都是通过造血系统移植过继的变形细胞产生器官（APO）或通过注射血浆被动。虽然被动转移在 16 年前就已经被描述过，但它仍然存在尽管有可能阐明体液机制，但尚未进行研究血吸虫抵抗力。初步研究证实存在来自其他类型的抗性蜗牛的血浆中的抗性因子，并且具有提供了关于效应持续时间、孢子被命运的新信息在具有被动转移阻力的蜗牛中，以及阻力因素分子量和来源。该提案旨在进一步描述被动转移对曼氏沙门氏菌的抗性并识别相关的等离子体阻力系数。