CARDIOVASCULAR APPLICATIONS OF VECTOR FLOW IMAGING

矢量流成像的心血管应用

• 批准号: 2378793
• 负责人: Gregg E. Trahey
• 金额: $ 21.89万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-03-01 至 2001-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2378793
• 关键词: cardiovascular imaging /visualization; clinical biomedical equipment; clinical research; computer program /software; computer simulation; diagnosis design /evaluation; human subject; image processing; ultrasound blood flow measurement

Quantitative and qualitative analyses of blood flow using continuous wave Doppler, pulsed Doppler, and Doppler color flow imaging techniques have become indispensable diagnostic tools in a wide range of clinical applications. However, the quality of information obtained from these techniques is severely compromised by two fundamental limitations: the ability to define only one projection of the three-dimensional blood velocity vector and, for the latter two techniques, aliasing. Our group has pioneered techniques and instrumentation that overcome these limitations and markedly extend the quality of flow data. Initial results indicate that two-dimensional vector flow (VF) techniques are capable of accurately quantifying velocities well beyond Doppler aliasing limits, along all directions within the imaging plane, without requiring Doppler angle estimation. In addition, initial in vitro studies have shown the ability to accurately quantify velocity profiles and volumetric flow rates in laminar vessels and jets, at flow angles of 90degrees where Doppler instruments fail. We propose to undertake simulation, in vitro, and clinical studies to examine novel vector flow techniques, based on parallel receive processing, that provide accurate, angle independent measurement of high blood velocities in clinically challenging applications. Specifically, we focus this research on quantification of regurgitant jets, in which high velocities and large flow gradients predominate. The performance of VF and Doppler methods of quantifying in vitro jet flow will be compared using a calibrated, computer-controlled phantom. These studies will include momentum and proximal flow analyses at clinically relevant velocities, noise levels, and turbulence. In addition, pilot clinical studies are proposed to investigate the performance of the VF methods in quantifying high velocity flow in mitral and aortic regurgitant jets, with comparison to continuous wave Doppler, the clinical gold standard for such measurements. It is hypothesized that VF imaging will increase the accuracy and ease of clinical measurements in such demanding applications and will provide consistent measurements regardless of the acoustic window utilized.

利用连续波对血液流动进行定量和定性分析 多普勒、脉冲多普勒和彩色多普勒血流成像技术 成为广泛临床应用中不可缺少的诊断工具 申请。然而，从这些信息中获得的信息的质量 技术受到两个基本限制的严重影响： 能够仅定义三维血液的一个投影 速度向量和后两种技术的锯齿。 我们团队开创了技术和仪器的先河， 这些限制和显著扩展了流动数据的质量。首字母 结果表明，二维矢量流(VF)技术是 能够精确地量化速度，远远超出多普勒混叠 极限，沿成像平面内的所有方向，而不需要 多普勒角估计。此外，初步的体外研究已经 展示了准确量化速度分布和体积的能力 层流容器和射流中的流量，在90度的流动角 多普勒仪出现故障。 我们建议进行模拟、体外和临床研究，以 研究基于并行接收的新型矢量流技术 处理，提供准确、角度无关的高度测量 在临床上具有挑战性的应用中的血流速度。具体来说， 我们的研究重点是回流射流的定量化，其中 高速度和大的流动梯度占主导地位。演出 VF和多普勒定量体外喷流的方法将是 使用经过校准的计算机控制的体模进行比较。这些研究 将包括临床相关的动量和近端血流分析 速度、噪声级和湍流。此外，试点临床 建议研究VF方法在以下方面的性能 定量二尖瓣和主动脉瓣返流的高速血流， 与临床金标准--连续波多普勒进行比较 用于这样的测量。假设VF成像将增加 临床测量的准确性和易用性在如此苛刻的情况下 应用程序，并将提供一致的测量结果，而不管 利用声学窗口。